Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study
Background: This study aimed to investigate whether sleep duration and/or quality are associated with incident diabetes mellitus (DM). Methods: A total of 8816 of 10,030 healthy participants were enrolled in a prospective cohort study. Sleep duration and quality questionnaires were completed. Sleep...
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/8/2899 |
| _version_ | 1797604855686103040 |
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| author | Jin ha Jang Wonjin Kim Jin Sil Moon Eun Roh Jun Goo Kang Seong Jin Lee Sung-Hee Ihm Ji Hye Huh |
| author_facet | Jin ha Jang Wonjin Kim Jin Sil Moon Eun Roh Jun Goo Kang Seong Jin Lee Sung-Hee Ihm Ji Hye Huh |
| author_sort | Jin ha Jang |
| collection | DOAJ |
| description | Background: This study aimed to investigate whether sleep duration and/or quality are associated with incident diabetes mellitus (DM). Methods: A total of 8816 of 10,030 healthy participants were enrolled in a prospective cohort study. Sleep duration and quality questionnaires were completed. Sleep quality was assessed using the Epworth Sleepiness Scale (ESS), which measures excessive daytime sleepiness in individuals. Results: During the 14-year follow-up period, 18% (1630/8816) were diagnosed with DM. A U-shaped relationship was observed between sleep duration and incident DM, with the highest risk observed when sleep duration was ≥10 h/day (hazard ratios (HR) 1.65 [1.25–2.17]). This group exhibited decreased insulin glycogenic index, a marker of insulin secretory function, during the study period. Among study participants who slept less than 10 h/day, the risk of incident DM increased when the ESS score was >10. Conclusions: We found that the association between sleep duration and incident DM was U-shaped; both short (≤5 h) and long (≥10 h) sleep durations were associated with an increased risk for the occurrence of incident DM. When sleep duration was 10 h or longer per day, there was a tendency to develop DM due to decreased insulin secretory function. |
| first_indexed | 2024-03-11T04:53:45Z |
| format | Article |
| id | doaj.art-1f9c38bfe9d146dfb8449fd82b0006b8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:53:45Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1f9c38bfe9d146dfb8449fd82b0006b82023-11-17T19:50:02ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01128289910.3390/jcm12082899Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort StudyJin ha Jang0Wonjin Kim1Jin Sil Moon2Eun Roh3Jun Goo Kang4Seong Jin Lee5Sung-Hee Ihm6Ji Hye Huh7Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Gangnam CHA Medical Center, CHA University School of Medicine, Seoul 06135, Republic of KoreaDepartment of Biostatistics, Yonsei University College of Medicine, Seoul 06273, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaBackground: This study aimed to investigate whether sleep duration and/or quality are associated with incident diabetes mellitus (DM). Methods: A total of 8816 of 10,030 healthy participants were enrolled in a prospective cohort study. Sleep duration and quality questionnaires were completed. Sleep quality was assessed using the Epworth Sleepiness Scale (ESS), which measures excessive daytime sleepiness in individuals. Results: During the 14-year follow-up period, 18% (1630/8816) were diagnosed with DM. A U-shaped relationship was observed between sleep duration and incident DM, with the highest risk observed when sleep duration was ≥10 h/day (hazard ratios (HR) 1.65 [1.25–2.17]). This group exhibited decreased insulin glycogenic index, a marker of insulin secretory function, during the study period. Among study participants who slept less than 10 h/day, the risk of incident DM increased when the ESS score was >10. Conclusions: We found that the association between sleep duration and incident DM was U-shaped; both short (≤5 h) and long (≥10 h) sleep durations were associated with an increased risk for the occurrence of incident DM. When sleep duration was 10 h or longer per day, there was a tendency to develop DM due to decreased insulin secretory function.https://www.mdpi.com/2077-0383/12/8/2899sleep durationsleep qualityexcessive daytime sleepinessdiabetesinsulin secretion |
| spellingShingle | Jin ha Jang Wonjin Kim Jin Sil Moon Eun Roh Jun Goo Kang Seong Jin Lee Sung-Hee Ihm Ji Hye Huh Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study Journal of Clinical Medicine sleep duration sleep quality excessive daytime sleepiness diabetes insulin secretion |
| title | Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study |
| title_full | Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study |
| title_fullStr | Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study |
| title_full_unstemmed | Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study |
| title_short | Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study |
| title_sort | association between sleep duration and incident diabetes mellitus in healthy subjects a 14 year longitudinal cohort study |
| topic | sleep duration sleep quality excessive daytime sleepiness diabetes insulin secretion |
| url | https://www.mdpi.com/2077-0383/12/8/2899 |
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