Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study
<p>Abstract</p> <p>Background</p> <p>Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tissues. We examined whethe...
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | http://www.cardiab.com/content/10/1/83 |
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| author | Eriksson Johan G Schwab Ursula Kolehmainen Marjukka Lindström Jaana Pulkkinen Leena Siitonen Niina Ilanne-Parikka Pirjo Keinänen-Kiukaanniemi Sirkka Tuomilehto Jaakko Uusitupa Matti |
| author_facet | Eriksson Johan G Schwab Ursula Kolehmainen Marjukka Lindström Jaana Pulkkinen Leena Siitonen Niina Ilanne-Parikka Pirjo Keinänen-Kiukaanniemi Sirkka Tuomilehto Jaakko Uusitupa Matti |
| author_sort | Eriksson Johan G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tissues. We examined whether genetic variation in <it>ADIPOR2 </it>predicts the development of cardiovascular disease (CVD) and/or Type 2 Diabetes (T2DM) in individuals with impaired glucose tolerance (IGT) participating the Finnish Diabetes Prevention Study (DPS).</p> <p>Methods</p> <p>CVD morbidity and mortality data were collected during a median follow-up of 10.2 years (range 1-13 years) and conversion from IGT to T2DM was assessed during a median follow-up of 7 years (range 1-11 years). Altogether eight SNPs in the <it>ADIPOR2 </it>locus were genotyped in 484 participants of the DPS. Moreover, the same SNPs were genotyped and the mRNA expression levels of <it>ADIPOR2 </it>were determined in peripheral blood mononuclear cells and subcutaneous adipose tissue samples derived from 56 individuals participating in the Genobin study.</p> <p>Results</p> <p>In the DPS population, four SNPs (rs10848554, rs11061937, rs1058322, rs16928751) were associated with CVD risk, and two remained significant (p = 0.014 for rs11061937 and p = 0.020 for rs1058322) when all four were included in the same multi-SNP model. Furthermore, the individuals homozygous for the rare minor alleles of rs11061946 and rs11061973 had increased risk of converting from IGT to T2DM. Allele-specific differences in the mRNA expression levels for the rs1058322 variant were seen in peripheral blood mononuclear cells derived from participants of the Genobin study.</p> <p>Conclusions</p> <p>Our results suggest that SNPs in the <it>ADIPOR2 </it>may modify the risk of CVD in individuals with IGT, possibly through alterations in the mRNA expression levels. In addition an independent genetic signal in <it>ADIPOR2 </it>locus may have an impact on the risk of developing T2DM in individuals with IGT.</p> <p>Trial registration number</p> <p>ClinicalTrials.gov <a href="http://www.clinicaltrials.gov/ct2/show/NCT00981877">NCT00518167</a></p> |
| first_indexed | 2024-12-18T05:38:30Z |
| format | Article |
| id | doaj.art-1f9ea8fb74c9410bb17b52337beb4c7d |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-18T05:38:30Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-1f9ea8fb74c9410bb17b52337beb4c7d2022-12-21T21:19:14ZengBMCCardiovascular Diabetology1475-28402011-09-011018310.1186/1475-2840-10-83Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention StudyEriksson Johan GSchwab UrsulaKolehmainen MarjukkaLindström JaanaPulkkinen LeenaSiitonen NiinaIlanne-Parikka PirjoKeinänen-Kiukaanniemi SirkkaTuomilehto JaakkoUusitupa Matti<p>Abstract</p> <p>Background</p> <p>Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tissues. We examined whether genetic variation in <it>ADIPOR2 </it>predicts the development of cardiovascular disease (CVD) and/or Type 2 Diabetes (T2DM) in individuals with impaired glucose tolerance (IGT) participating the Finnish Diabetes Prevention Study (DPS).</p> <p>Methods</p> <p>CVD morbidity and mortality data were collected during a median follow-up of 10.2 years (range 1-13 years) and conversion from IGT to T2DM was assessed during a median follow-up of 7 years (range 1-11 years). Altogether eight SNPs in the <it>ADIPOR2 </it>locus were genotyped in 484 participants of the DPS. Moreover, the same SNPs were genotyped and the mRNA expression levels of <it>ADIPOR2 </it>were determined in peripheral blood mononuclear cells and subcutaneous adipose tissue samples derived from 56 individuals participating in the Genobin study.</p> <p>Results</p> <p>In the DPS population, four SNPs (rs10848554, rs11061937, rs1058322, rs16928751) were associated with CVD risk, and two remained significant (p = 0.014 for rs11061937 and p = 0.020 for rs1058322) when all four were included in the same multi-SNP model. Furthermore, the individuals homozygous for the rare minor alleles of rs11061946 and rs11061973 had increased risk of converting from IGT to T2DM. Allele-specific differences in the mRNA expression levels for the rs1058322 variant were seen in peripheral blood mononuclear cells derived from participants of the Genobin study.</p> <p>Conclusions</p> <p>Our results suggest that SNPs in the <it>ADIPOR2 </it>may modify the risk of CVD in individuals with IGT, possibly through alterations in the mRNA expression levels. In addition an independent genetic signal in <it>ADIPOR2 </it>locus may have an impact on the risk of developing T2DM in individuals with IGT.</p> <p>Trial registration number</p> <p>ClinicalTrials.gov <a href="http://www.clinicaltrials.gov/ct2/show/NCT00981877">NCT00518167</a></p>http://www.cardiab.com/content/10/1/83Adiponectinadiponectin receptor 2genesingle nucleotide polymorphismcardiovascular diseasetype 2 diabetes |
| spellingShingle | Eriksson Johan G Schwab Ursula Kolehmainen Marjukka Lindström Jaana Pulkkinen Leena Siitonen Niina Ilanne-Parikka Pirjo Keinänen-Kiukaanniemi Sirkka Tuomilehto Jaakko Uusitupa Matti Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study Cardiovascular Diabetology Adiponectin adiponectin receptor 2 gene single nucleotide polymorphism cardiovascular disease type 2 diabetes |
| title | Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study |
| title_full | Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study |
| title_fullStr | Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study |
| title_full_unstemmed | Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study |
| title_short | Association of <it>ADIPOR2 </it>gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study |
| title_sort | association of it adipor2 it gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance the finnish diabetes prevention study |
| topic | Adiponectin adiponectin receptor 2 gene single nucleotide polymorphism cardiovascular disease type 2 diabetes |
| url | http://www.cardiab.com/content/10/1/83 |
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