Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition
Highlights 1. Androgen excess in PCOS model is associated with decreased markers of mitochondrial content in both subcutaneous and visceral white adipose tissue. 2. Androgen excess in PCOS model is associated with increased frequency of small adipocytes in subcutaneous white adipose tissue while dec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-022-00455-x |
| _version_ | 1828358251971870720 |
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| author | Jacob E. Pruett Steven J. Everman Ngoc H. Hoang Faridah Salau Lucy C. Taylor Kristin S. Edwards Jonathan P. Hosler Alexandra M. Huffman Damian G. Romero Licy L. Yanes Cardozo |
| author_facet | Jacob E. Pruett Steven J. Everman Ngoc H. Hoang Faridah Salau Lucy C. Taylor Kristin S. Edwards Jonathan P. Hosler Alexandra M. Huffman Damian G. Romero Licy L. Yanes Cardozo |
| author_sort | Jacob E. Pruett |
| collection | DOAJ |
| description | Highlights 1. Androgen excess in PCOS model is associated with decreased markers of mitochondrial content in both subcutaneous and visceral white adipose tissue. 2. Androgen excess in PCOS model is associated with increased frequency of small adipocytes in subcutaneous white adipose tissue while decreasing frequency of small adipocytes in visceral white adipose tissue. 3. SGLT2 inhibition did not modify markers of mitochondrial content or oxidative stress in either subcutaneous or visceral white adipose tissue in PCOS model. 4. SGLT2 inhibition increased frequency of small adipocytes in both subcutaneous and visceral white adipose tissue in control rats; however, SGLT2 inhibition only increased frequency of small adipocytes in visceral white adipose tissue in PCOS model. |
| first_indexed | 2024-04-14T03:26:56Z |
| format | Article |
| id | doaj.art-1fa16c82e76e4c35adfc865f1a25a9d9 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-14T03:26:56Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-1fa16c82e76e4c35adfc865f1a25a9d92022-12-22T02:15:08ZengBMCBiology of Sex Differences2042-64102022-08-0113111710.1186/s13293-022-00455-xMitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibitionJacob E. Pruett0Steven J. Everman1Ngoc H. Hoang2Faridah Salau3Lucy C. Taylor4Kristin S. Edwards5Jonathan P. Hosler6Alexandra M. Huffman7Damian G. Romero8Licy L. Yanes Cardozo9Department of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterDepartment of Cell and Molecular Biology, University of Mississippi Medical CenterHighlights 1. Androgen excess in PCOS model is associated with decreased markers of mitochondrial content in both subcutaneous and visceral white adipose tissue. 2. Androgen excess in PCOS model is associated with increased frequency of small adipocytes in subcutaneous white adipose tissue while decreasing frequency of small adipocytes in visceral white adipose tissue. 3. SGLT2 inhibition did not modify markers of mitochondrial content or oxidative stress in either subcutaneous or visceral white adipose tissue in PCOS model. 4. SGLT2 inhibition increased frequency of small adipocytes in both subcutaneous and visceral white adipose tissue in control rats; however, SGLT2 inhibition only increased frequency of small adipocytes in visceral white adipose tissue in PCOS model.https://doi.org/10.1186/s13293-022-00455-xPolycystic ovary syndromeAndrogensMitochondrial dysfunctionWhite adipose tissueSodium–glucose cotransporter-2 |
| spellingShingle | Jacob E. Pruett Steven J. Everman Ngoc H. Hoang Faridah Salau Lucy C. Taylor Kristin S. Edwards Jonathan P. Hosler Alexandra M. Huffman Damian G. Romero Licy L. Yanes Cardozo Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition Biology of Sex Differences Polycystic ovary syndrome Androgens Mitochondrial dysfunction White adipose tissue Sodium–glucose cotransporter-2 |
| title | Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition |
| title_full | Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition |
| title_fullStr | Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition |
| title_full_unstemmed | Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition |
| title_short | Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition |
| title_sort | mitochondrial function and oxidative stress in white adipose tissue in a rat model of pcos effect of sglt2 inhibition |
| topic | Polycystic ovary syndrome Androgens Mitochondrial dysfunction White adipose tissue Sodium–glucose cotransporter-2 |
| url | https://doi.org/10.1186/s13293-022-00455-x |
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