Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics
Neuroendocrine neoplasms (NENs) are a group of lesions originating from cells of the diffuse neuroendocrine system. NENs may involve different sites, including the gastrointestinal tract (GEP-NENs). The incidence and prevalence of GEP-NENs has been constantly rising thanks to the increased diagnosti...
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MDPI AG
2023-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/18/2877 |
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| author | Federica De Muzio Fabio Pellegrino Roberta Fusco Salvatore Tafuto Mariano Scaglione Alessandro Ottaiano Antonella Petrillo Francesco Izzo Vincenza Granata |
| author_facet | Federica De Muzio Fabio Pellegrino Roberta Fusco Salvatore Tafuto Mariano Scaglione Alessandro Ottaiano Antonella Petrillo Francesco Izzo Vincenza Granata |
| author_sort | Federica De Muzio |
| collection | DOAJ |
| description | Neuroendocrine neoplasms (NENs) are a group of lesions originating from cells of the diffuse neuroendocrine system. NENs may involve different sites, including the gastrointestinal tract (GEP-NENs). The incidence and prevalence of GEP-NENs has been constantly rising thanks to the increased diagnostic power of imaging and immuno–histochemistry. Despite the plethora of biochemical markers and imaging techniques, the prognosis and therapeutic choice in GEP-NENs still represents a challenge, mainly due to the great heterogeneity in terms of tumor lesions and clinical behavior. The concept that biomedical images contain information about tissue heterogeneity and pathological processes invisible to the human eye is now well established. From this substrate comes the idea of radiomics. Computational analysis has achieved promising results in several oncological settings, and the use of radiomics in different types of GEP-NENs is growing in the field of research, yet with conflicting results. The aim of this narrative review is to provide a comprehensive update on the role of radiomics on GEP-NEN management, focusing on the main clinical aspects analyzed by most existing reports: predicting tumor grade, distinguishing NET from other tumors, and prognosis assessment. |
| first_indexed | 2024-03-10T22:52:57Z |
| format | Article |
| id | doaj.art-1fa244e7422646188fbb65bfb95a8598 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T22:52:57Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1fa244e7422646188fbb65bfb95a85982023-11-19T10:12:50ZengMDPI AGDiagnostics2075-44182023-09-011318287710.3390/diagnostics13182877Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of RadiomicsFederica De Muzio0Fabio Pellegrino1Roberta Fusco2Salvatore Tafuto3Mariano Scaglione4Alessandro Ottaiano5Antonella Petrillo6Francesco Izzo7Vincenza Granata8Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, ItalyRadiology Division, S. Bonifacio Hospital, 37047 Verona, ItalyMedical Oncology Division, Igea SpA, 80013 Napoli, ItalyUnit of Sarcomi e Tumori Rari, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, 80131 Naples, ItalyDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, ItalyUnit for Innovative Therapies of Abdominal Metastastes, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, 80131 Naples, ItalyDivision of Hepatobiliary Surgery, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, 80131 Naples, ItalyDivision of Radiology, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, 80131 Naples, ItalyNeuroendocrine neoplasms (NENs) are a group of lesions originating from cells of the diffuse neuroendocrine system. NENs may involve different sites, including the gastrointestinal tract (GEP-NENs). The incidence and prevalence of GEP-NENs has been constantly rising thanks to the increased diagnostic power of imaging and immuno–histochemistry. Despite the plethora of biochemical markers and imaging techniques, the prognosis and therapeutic choice in GEP-NENs still represents a challenge, mainly due to the great heterogeneity in terms of tumor lesions and clinical behavior. The concept that biomedical images contain information about tissue heterogeneity and pathological processes invisible to the human eye is now well established. From this substrate comes the idea of radiomics. Computational analysis has achieved promising results in several oncological settings, and the use of radiomics in different types of GEP-NENs is growing in the field of research, yet with conflicting results. The aim of this narrative review is to provide a comprehensive update on the role of radiomics on GEP-NEN management, focusing on the main clinical aspects analyzed by most existing reports: predicting tumor grade, distinguishing NET from other tumors, and prognosis assessment.https://www.mdpi.com/2075-4418/13/18/2877neuroendocrine neoplasmsimagingcomputed tomographymagnetic resonance imagingradiomics |
| spellingShingle | Federica De Muzio Fabio Pellegrino Roberta Fusco Salvatore Tafuto Mariano Scaglione Alessandro Ottaiano Antonella Petrillo Francesco Izzo Vincenza Granata Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics Diagnostics neuroendocrine neoplasms imaging computed tomography magnetic resonance imaging radiomics |
| title | Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics |
| title_full | Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics |
| title_fullStr | Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics |
| title_full_unstemmed | Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics |
| title_short | Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics |
| title_sort | prognostic assessment of gastropancreatic neuroendocrine neoplasm prospects and limits of radiomics |
| topic | neuroendocrine neoplasms imaging computed tomography magnetic resonance imaging radiomics |
| url | https://www.mdpi.com/2075-4418/13/18/2877 |
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