Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure
Abstract Synchronized diaphragmatic stimulation (SDS) is a novel extra‐cardiac device‐based therapy for symptomatic heart failure with reduced ejection fraction. SDS provides imperceptible chronic stimulation of the diaphragm through a laparoscopically implanted system consisting of an implantable p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13882 |
| _version_ | 1811288969097248768 |
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| author | Lee R. Goldberg Ana Jorbenadze Tamaz Shaburishvilli Michael J. Mirro Marat Fudim Michel Zuber Simon F. Stämpfli Felix C. Tanner Paul Erne John G. Cleland |
| author_facet | Lee R. Goldberg Ana Jorbenadze Tamaz Shaburishvilli Michael J. Mirro Marat Fudim Michel Zuber Simon F. Stämpfli Felix C. Tanner Paul Erne John G. Cleland |
| author_sort | Lee R. Goldberg |
| collection | DOAJ |
| description | Abstract Synchronized diaphragmatic stimulation (SDS) is a novel extra‐cardiac device‐based therapy for symptomatic heart failure with reduced ejection fraction. SDS provides imperceptible chronic stimulation of the diaphragm through a laparoscopically implanted system consisting of an implantable pulse generator and two sensing/stimulating leads affixed to the inferior surface of the diaphragm delivering imperceptible R‐wave gaited pulses that alter intrathoracic pressure improving ventricular filling and cardiac output. We describe, in a man with a history of myocardial infarctions resulting in heart failure and persistent New York Heart Association Class III symptoms despite standard therapies, the successful implantation of SDS resulting in improved quality of life, N‐terminal pro brain natriuretic peptide, cardiac function, and exercise tolerance through 12 months of follow‐up. Randomized trials are now required to validate these findings. |
| first_indexed | 2024-04-13T03:46:35Z |
| format | Article |
| id | doaj.art-1fa41ca717bc4aae95fcb70b2b0322a8 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-13T03:46:35Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-1fa41ca717bc4aae95fcb70b2b0322a82022-12-22T03:03:59ZengWileyESC Heart Failure2055-58222022-06-01931677168110.1002/ehf2.13882Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failureLee R. Goldberg0Ana Jorbenadze1Tamaz Shaburishvilli2Michael J. Mirro3Marat Fudim4Michel Zuber5Simon F. Stämpfli6Felix C. Tanner7Paul Erne8John G. Cleland9Section of Advanced Heart Failure and Cardiac Transplant, Division of Cardiovascular Medicine, Perelman School of Medicine University of Pennsylvania 3400 Civic Center Boulevard, 11‐171 South Tower Philadelphia PA 19104 USAHeart and Vascular Clinic Tbilisi Republic of GeorgiaHeart and Vascular Clinic Tbilisi Republic of GeorgiaIndiana University and Parkview Health Fort Wayne IN USADepartment of Medicine Duke University Medical Center Durham NC USAHeart Center Kantonsspital Aarau SwitzerlandHeart Center, University Hospital, Zürich and Heart Center Luzerner Kantonsspital Lucerne SwitzerlandHeart Center University Hospital Zürich. SwitzerlandFaculty of Biomedical Sciences Universita della Svizzera Italiana Lugano SwitzerlandRobertson Centre for Biostatistics University of Glasgow Glasgow UKAbstract Synchronized diaphragmatic stimulation (SDS) is a novel extra‐cardiac device‐based therapy for symptomatic heart failure with reduced ejection fraction. SDS provides imperceptible chronic stimulation of the diaphragm through a laparoscopically implanted system consisting of an implantable pulse generator and two sensing/stimulating leads affixed to the inferior surface of the diaphragm delivering imperceptible R‐wave gaited pulses that alter intrathoracic pressure improving ventricular filling and cardiac output. We describe, in a man with a history of myocardial infarctions resulting in heart failure and persistent New York Heart Association Class III symptoms despite standard therapies, the successful implantation of SDS resulting in improved quality of life, N‐terminal pro brain natriuretic peptide, cardiac function, and exercise tolerance through 12 months of follow‐up. Randomized trials are now required to validate these findings.https://doi.org/10.1002/ehf2.13882Congestive heart failureSynchronized diaphragmatic stimulationAcute cardiac haemodynamics |
| spellingShingle | Lee R. Goldberg Ana Jorbenadze Tamaz Shaburishvilli Michael J. Mirro Marat Fudim Michel Zuber Simon F. Stämpfli Felix C. Tanner Paul Erne John G. Cleland Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure ESC Heart Failure Congestive heart failure Synchronized diaphragmatic stimulation Acute cardiac haemodynamics |
| title | Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure |
| title_full | Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure |
| title_fullStr | Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure |
| title_full_unstemmed | Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure |
| title_short | Synchronized diaphragmatic stimulation: a case report of a novel extra‐cardiac intervention for chronic heart failure |
| title_sort | synchronized diaphragmatic stimulation a case report of a novel extra cardiac intervention for chronic heart failure |
| topic | Congestive heart failure Synchronized diaphragmatic stimulation Acute cardiac haemodynamics |
| url | https://doi.org/10.1002/ehf2.13882 |
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