Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response
Abstract Several limitations of [18F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [11C]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor tissues, PET probes with tumor-specific molecular targe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29166-y |
| _version_ | 1811171741333979136 |
|---|---|
| author | Satoshi Nozaki Yuka Nakatani Aya Mawatari Nina Shibata William E. Hume Emi Hayashinaka Yasuhiro Wada Hisashi Doi Yasuyoshi Watanabe |
| author_facet | Satoshi Nozaki Yuka Nakatani Aya Mawatari Nina Shibata William E. Hume Emi Hayashinaka Yasuhiro Wada Hisashi Doi Yasuyoshi Watanabe |
| author_sort | Satoshi Nozaki |
| collection | DOAJ |
| description | Abstract Several limitations of [18F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [11C]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor tissues, PET probes with tumor-specific molecular targets have been actively developed. [18F]FIMP was found to be highly accumulated in LAT1-positive tumors but not in inflamed tissue. The aim of this study was to explore whether [18F]FIMP can be used for the early-phase evaluation of radiotherapy accompanied by inflammation, and compare its effectiveness with those of [11C]MET and [18F]FDG. Tumor uptake of [18F]FIMP decreased at day 1 after irradiation, and remained low until day 14. Comparatively, that of [18F]FDG initially decreased at day 3 but was transiently elevated at day 7 and then decreased again at day 10. Decreased tumor uptake of [11C]MET was observed at day 10. In line with the uptake of [18F]FIMP, the ratio of Ki-67 immuno-positive cells in tumor tissues significantly decreased at day 1, 7, and 10 as compared with that in the control. These findings suggest that [18F]FIMP may be a PET probe involved in the early detection and prediction of radiotherapy efficacy, although further clarification is needed. |
| first_indexed | 2024-04-10T17:19:06Z |
| format | Article |
| id | doaj.art-1fa436ce421b40bf8d6b1229ce5c0cff |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T17:19:06Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1fa436ce421b40bf8d6b1229ce5c0cff2023-02-05T12:11:34ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-29166-yComparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy responseSatoshi Nozaki0Yuka Nakatani1Aya Mawatari2Nina Shibata3William E. Hume4Emi Hayashinaka5Yasuhiro Wada6Hisashi Doi7Yasuyoshi Watanabe8Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics ResearchNovel PET Diagnostics Laboratory, RIKEN Innovation CenterLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics ResearchAbstract Several limitations of [18F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [11C]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor tissues, PET probes with tumor-specific molecular targets have been actively developed. [18F]FIMP was found to be highly accumulated in LAT1-positive tumors but not in inflamed tissue. The aim of this study was to explore whether [18F]FIMP can be used for the early-phase evaluation of radiotherapy accompanied by inflammation, and compare its effectiveness with those of [11C]MET and [18F]FDG. Tumor uptake of [18F]FIMP decreased at day 1 after irradiation, and remained low until day 14. Comparatively, that of [18F]FDG initially decreased at day 3 but was transiently elevated at day 7 and then decreased again at day 10. Decreased tumor uptake of [11C]MET was observed at day 10. In line with the uptake of [18F]FIMP, the ratio of Ki-67 immuno-positive cells in tumor tissues significantly decreased at day 1, 7, and 10 as compared with that in the control. These findings suggest that [18F]FIMP may be a PET probe involved in the early detection and prediction of radiotherapy efficacy, although further clarification is needed.https://doi.org/10.1038/s41598-023-29166-y |
| spellingShingle | Satoshi Nozaki Yuka Nakatani Aya Mawatari Nina Shibata William E. Hume Emi Hayashinaka Yasuhiro Wada Hisashi Doi Yasuyoshi Watanabe Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response Scientific Reports |
| title | Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response |
| title_full | Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response |
| title_fullStr | Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response |
| title_full_unstemmed | Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response |
| title_short | Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response |
| title_sort | comparison of 18f fimp 11c met and 18f fdg pet for early phase assessment of radiotherapy response |
| url | https://doi.org/10.1038/s41598-023-29166-y |
| work_keys_str_mv | AT satoshinozaki comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT yukanakatani comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT ayamawatari comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT ninashibata comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT williamehume comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT emihayashinaka comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT yasuhirowada comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT hisashidoi comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse AT yasuyoshiwatanabe comparisonof18ffimp11cmetand18ffdgpetforearlyphaseassessmentofradiotherapyresponse |