Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice
The prevalence of metabolic diseases is rapidly increasing and a principal contributor to this is diet, including increased consumption of energy-rich foods and foods with added phosphates. Exercise is an effective therapeutic approach to combat metabolic disease. While exercise is effective to comb...
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/6/1201 |
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| author | Pablo Vidal Lisa A. Baer Elisa Félix-Soriano Felix T. Yang Daniel A. Branch Kedryn K. Baskin Kristin I. Stanford |
| author_facet | Pablo Vidal Lisa A. Baer Elisa Félix-Soriano Felix T. Yang Daniel A. Branch Kedryn K. Baskin Kristin I. Stanford |
| author_sort | Pablo Vidal |
| collection | DOAJ |
| description | The prevalence of metabolic diseases is rapidly increasing and a principal contributor to this is diet, including increased consumption of energy-rich foods and foods with added phosphates. Exercise is an effective therapeutic approach to combat metabolic disease. While exercise is effective to combat the detrimental effects of a high-fat diet on metabolic health, the effects of exercise on a high-phosphate diet have not been thoroughly investigated. Here, we investigated the effects of a high-fat or high-phosphate diet in the presence or absence of voluntary exercise on metabolic function in male mice. To do this, mice were fed a low-fat, normal-phosphate diet (LFPD), a high-phosphate diet (HPD) or a high-fat diet (HFD) for 6 weeks and then subdivided into either sedentary or exercised (housed with running wheels) for an additional 8 weeks. An HFD severely impaired metabolic function in mice, increasing total fat mass and worsening whole-body glucose tolerance, while HPD did not induce any notable effects on glucose metabolism. Exercise reverted most of the detrimental metabolic adaptations induced by HFD, decreasing total fat mass and restoring whole-body glucose tolerance and insulin sensitivity. Interestingly, voluntary exercise had a similar effect on LFPD and HPD mice. These data suggest that a high-phosphate diet does not significantly impair glucose metabolism in sedentary or voluntary exercised conditions. |
| first_indexed | 2024-03-09T13:05:25Z |
| format | Article |
| id | doaj.art-1fa671eee94b40a48557c71d0dc18ebd |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T13:05:25Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1fa671eee94b40a48557c71d0dc18ebd2023-11-30T21:49:25ZengMDPI AGNutrients2072-66432022-03-01146120110.3390/nu14061201Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male MicePablo Vidal0Lisa A. Baer1Elisa Félix-Soriano2Felix T. Yang3Daniel A. Branch4Kedryn K. Baskin5Kristin I. Stanford6Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USAThe prevalence of metabolic diseases is rapidly increasing and a principal contributor to this is diet, including increased consumption of energy-rich foods and foods with added phosphates. Exercise is an effective therapeutic approach to combat metabolic disease. While exercise is effective to combat the detrimental effects of a high-fat diet on metabolic health, the effects of exercise on a high-phosphate diet have not been thoroughly investigated. Here, we investigated the effects of a high-fat or high-phosphate diet in the presence or absence of voluntary exercise on metabolic function in male mice. To do this, mice were fed a low-fat, normal-phosphate diet (LFPD), a high-phosphate diet (HPD) or a high-fat diet (HFD) for 6 weeks and then subdivided into either sedentary or exercised (housed with running wheels) for an additional 8 weeks. An HFD severely impaired metabolic function in mice, increasing total fat mass and worsening whole-body glucose tolerance, while HPD did not induce any notable effects on glucose metabolism. Exercise reverted most of the detrimental metabolic adaptations induced by HFD, decreasing total fat mass and restoring whole-body glucose tolerance and insulin sensitivity. Interestingly, voluntary exercise had a similar effect on LFPD and HPD mice. These data suggest that a high-phosphate diet does not significantly impair glucose metabolism in sedentary or voluntary exercised conditions.https://www.mdpi.com/2072-6643/14/6/1201exercisehigh-fat diethigh-phosphate dietadipose tissuemetabolism |
| spellingShingle | Pablo Vidal Lisa A. Baer Elisa Félix-Soriano Felix T. Yang Daniel A. Branch Kedryn K. Baskin Kristin I. Stanford Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice Nutrients exercise high-fat diet high-phosphate diet adipose tissue metabolism |
| title | Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice |
| title_full | Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice |
| title_fullStr | Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice |
| title_full_unstemmed | Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice |
| title_short | Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice |
| title_sort | distinct effects of high fat and high phosphate diet on glucose metabolism and the response to voluntary exercise in male mice |
| topic | exercise high-fat diet high-phosphate diet adipose tissue metabolism |
| url | https://www.mdpi.com/2072-6643/14/6/1201 |
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