Retinal honeycomb appearance and its role in patients with X-linked retinoschisis
Abstract Background To investigate the clinical characteristics of retinal honeycomb appearance in a large cohort of patients with X-linked retinoschisis (XLRS) and to determine whether it is associated with complications like retinal detachment (RD) and vitreous hemorrhage (VH). Methods A retrospec...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-02835-2 |
| _version_ | 1827984812999180288 |
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| author | Jing Ma Jing-Hua Liu Song-Feng Li Yan Ma Guang-Da Deng Liang Li Ming-Zhen Yuan Hai Lu |
| author_facet | Jing Ma Jing-Hua Liu Song-Feng Li Yan Ma Guang-Da Deng Liang Li Ming-Zhen Yuan Hai Lu |
| author_sort | Jing Ma |
| collection | DOAJ |
| description | Abstract Background To investigate the clinical characteristics of retinal honeycomb appearance in a large cohort of patients with X-linked retinoschisis (XLRS) and to determine whether it is associated with complications like retinal detachment (RD) and vitreous hemorrhage (VH). Methods A retrospective observational case series. A chart review of medical records, wide-field fundus imaging, and optical coherence tomography (OCT) was performed on 78 patients (153 eyes) diagnosed with XLRS at Beijing Tongren eye center between Dec 2017 and Feb 2022. The chi-square test or Fisher exact test was performed on the 2 × 2 cross-tabulations of honeycomb appearance and other peripheral retinal findings and complications. Results Thirty-eight patients (48.7%), and 60 eyes (39.2%) had a honeycomb appearance of different areas on the fundus. The supratemporal quadrant was the most commonly affected (45 eyes, 75.0%), followed by the infratemporal (23 eyes, 38.3%), the infranasal (10 eyes,16.7%), and supranasal (9 eyes,15.0%). The appearance was significantly associated with peripheral retinoschisis, inner retinal layer break, outer retinal layer break, RD, and rhegmatogenous retinal detachment (RRD) (p < 0.01, p = 0.032, p < 0.01, p = 0.008, p < 0.01, respectively). All the eyes complicated with RRD had the appearance. None of the eyes without the appearance had RRD. Conclusions The data suggest that the honeycomb appearance is not uncommon in patients with XLRS and is more likely to be accompanied by an RRD, and inner and outer layer breaks, thus should be treated with caution and close observation. |
| first_indexed | 2024-04-09T23:04:53Z |
| format | Article |
| id | doaj.art-1fa81f2623684234837c16d429d59587 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-09T23:04:53Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-1fa81f2623684234837c16d429d595872023-03-22T10:44:19ZengBMCBMC Ophthalmology1471-24152023-03-012311710.1186/s12886-023-02835-2Retinal honeycomb appearance and its role in patients with X-linked retinoschisisJing Ma0Jing-Hua Liu1Song-Feng Li2Yan Ma3Guang-Da Deng4Liang Li5Ming-Zhen Yuan6Hai Lu7Beijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual ScienceAbstract Background To investigate the clinical characteristics of retinal honeycomb appearance in a large cohort of patients with X-linked retinoschisis (XLRS) and to determine whether it is associated with complications like retinal detachment (RD) and vitreous hemorrhage (VH). Methods A retrospective observational case series. A chart review of medical records, wide-field fundus imaging, and optical coherence tomography (OCT) was performed on 78 patients (153 eyes) diagnosed with XLRS at Beijing Tongren eye center between Dec 2017 and Feb 2022. The chi-square test or Fisher exact test was performed on the 2 × 2 cross-tabulations of honeycomb appearance and other peripheral retinal findings and complications. Results Thirty-eight patients (48.7%), and 60 eyes (39.2%) had a honeycomb appearance of different areas on the fundus. The supratemporal quadrant was the most commonly affected (45 eyes, 75.0%), followed by the infratemporal (23 eyes, 38.3%), the infranasal (10 eyes,16.7%), and supranasal (9 eyes,15.0%). The appearance was significantly associated with peripheral retinoschisis, inner retinal layer break, outer retinal layer break, RD, and rhegmatogenous retinal detachment (RRD) (p < 0.01, p = 0.032, p < 0.01, p = 0.008, p < 0.01, respectively). All the eyes complicated with RRD had the appearance. None of the eyes without the appearance had RRD. Conclusions The data suggest that the honeycomb appearance is not uncommon in patients with XLRS and is more likely to be accompanied by an RRD, and inner and outer layer breaks, thus should be treated with caution and close observation.https://doi.org/10.1186/s12886-023-02835-2Retinoschisis/congenitalDiagnostic imagingRetina |
| spellingShingle | Jing Ma Jing-Hua Liu Song-Feng Li Yan Ma Guang-Da Deng Liang Li Ming-Zhen Yuan Hai Lu Retinal honeycomb appearance and its role in patients with X-linked retinoschisis BMC Ophthalmology Retinoschisis/congenital Diagnostic imaging Retina |
| title | Retinal honeycomb appearance and its role in patients with X-linked retinoschisis |
| title_full | Retinal honeycomb appearance and its role in patients with X-linked retinoschisis |
| title_fullStr | Retinal honeycomb appearance and its role in patients with X-linked retinoschisis |
| title_full_unstemmed | Retinal honeycomb appearance and its role in patients with X-linked retinoschisis |
| title_short | Retinal honeycomb appearance and its role in patients with X-linked retinoschisis |
| title_sort | retinal honeycomb appearance and its role in patients with x linked retinoschisis |
| topic | Retinoschisis/congenital Diagnostic imaging Retina |
| url | https://doi.org/10.1186/s12886-023-02835-2 |
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