A Novel Fragmentation Sensitivity Index Determines the Susceptibility of Red Blood Cells to Mechanical Trauma

A Novel Fragmentation Sensitivity Index Determines the Susceptibility of Red Blood Cells to Mechanical Trauma

Supraphysiological shear stresses (SSs) induce irreversible impairments of red blood cell (RBC) deformability, overstretching of RBC membrane, or fragmentation of RBCs that causes free hemoglobin to be released into plasma, which may lead to anemia. The magnitude and exposure tisme of the SSs are tw...

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Bibliographic Details
Main Authors: Elif Ugurel, Evrim Goksel, Polat Goktas, Neslihan Cilek, Dila Atar, Ozlem Yalcin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
supra-physiological shear stress
red blood cell fragmentation
oxidative stress
metabolic depletion
mechanical risk sensitivity
fragmentaton sensitivity index
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.714157/full

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