Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study
Background and Aims: Anaesthetics are implicated in cognitive dysfunction, taste and odour deficits in the postoperative period. We aimed to assess the effect of isoflurane, sevoflurane, propofol and regional anaesthesia on the olfactory threshold, olfactory identification and endocrine regulation o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2018;volume=62;issue=8;spage=592;epage=598;aulast=Saravanan |
| _version_ | 1828498983694106624 |
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| author | Balachandar Saravanan Pankaj Kundra Sandeep Kumar Mishra Gopalakrishnan Surianarayanan Pradipta Kumar Parida |
| author_facet | Balachandar Saravanan Pankaj Kundra Sandeep Kumar Mishra Gopalakrishnan Surianarayanan Pradipta Kumar Parida |
| author_sort | Balachandar Saravanan |
| collection | DOAJ |
| description | Background and Aims: Anaesthetics are implicated in cognitive dysfunction, taste and odour deficits in the postoperative period. We aimed to assess the effect of isoflurane, sevoflurane, propofol and regional anaesthesia on the olfactory threshold, olfactory identification and endocrine regulation of associative memory in the postoperative period. Methods: In this observer-blinded randomised controlled study, 164 patients (>50 years) with the American Society of Anesthesiologists I and II status were randomised into one of four groups to receive regional anaesthesia, general anaesthesia with sevoflurane, general anaesthesia with isoflurane and total intravenous anaesthesia with propofol. Hindi Mental State Examination, olfactory threshold and olfactory identification were tested at 12 h preoperatively (T0), at 3 h postoperatively (T1) and at the time of discharge or postoperative day 3 (T2). In addition, serum melatonin levels were estimated at T0 and T1. The olfactory threshold was tested with n-butyl alcohol and olfactory identification with the University of Pennsylvania Smell Identification Test (UPSIT). Data were analysed using the one-way analysis of variance, Kruskal-Wallis or Mann-whitney tests. Results: The olfactory identification scores were lower with patients receiving sevoflurane-based anaesthesia at 3 h postoperatively (T1) when compared to preoperative (T0) (median 19.5 vs. 22; P = 0.01). This was accompanied by a significant postoperative reduction of plasma melatonin levels in sevoflurane group when compared to other groups (17.34 ± 4.8 pg/ml vs 23.2 ± 3.5 pg/ml; P < 0.001). Conclusion: Sevoflurane was associated with short-term olfactory identification impairment with a concomitant reduction in melatonin levels illustrating a possible humoral mechanism. |
| first_indexed | 2024-12-11T13:16:45Z |
| format | Article |
| id | doaj.art-1faa9be1e016478086ba8bc15ddd5121 |
| institution | Directory Open Access Journal |
| issn | 0019-5049 0976-2817 |
| language | English |
| last_indexed | 2024-12-11T13:16:45Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-1faa9be1e016478086ba8bc15ddd51212022-12-22T01:06:01ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50490976-28172018-01-0162859259810.4103/ija.IJA_245_18Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled studyBalachandar SaravananPankaj KundraSandeep Kumar MishraGopalakrishnan SurianarayananPradipta Kumar ParidaBackground and Aims: Anaesthetics are implicated in cognitive dysfunction, taste and odour deficits in the postoperative period. We aimed to assess the effect of isoflurane, sevoflurane, propofol and regional anaesthesia on the olfactory threshold, olfactory identification and endocrine regulation of associative memory in the postoperative period. Methods: In this observer-blinded randomised controlled study, 164 patients (>50 years) with the American Society of Anesthesiologists I and II status were randomised into one of four groups to receive regional anaesthesia, general anaesthesia with sevoflurane, general anaesthesia with isoflurane and total intravenous anaesthesia with propofol. Hindi Mental State Examination, olfactory threshold and olfactory identification were tested at 12 h preoperatively (T0), at 3 h postoperatively (T1) and at the time of discharge or postoperative day 3 (T2). In addition, serum melatonin levels were estimated at T0 and T1. The olfactory threshold was tested with n-butyl alcohol and olfactory identification with the University of Pennsylvania Smell Identification Test (UPSIT). Data were analysed using the one-way analysis of variance, Kruskal-Wallis or Mann-whitney tests. Results: The olfactory identification scores were lower with patients receiving sevoflurane-based anaesthesia at 3 h postoperatively (T1) when compared to preoperative (T0) (median 19.5 vs. 22; P = 0.01). This was accompanied by a significant postoperative reduction of plasma melatonin levels in sevoflurane group when compared to other groups (17.34 ± 4.8 pg/ml vs 23.2 ± 3.5 pg/ml; P < 0.001). Conclusion: Sevoflurane was associated with short-term olfactory identification impairment with a concomitant reduction in melatonin levels illustrating a possible humoral mechanism.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2018;volume=62;issue=8;spage=592;epage=598;aulast=SaravananGeneral anaesthesianeurotoxicityolfactionolfactory identificationsevoflurane |
| spellingShingle | Balachandar Saravanan Pankaj Kundra Sandeep Kumar Mishra Gopalakrishnan Surianarayanan Pradipta Kumar Parida Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study Indian Journal of Anaesthesia General anaesthesia neurotoxicity olfaction olfactory identification sevoflurane |
| title | Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study |
| title_full | Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study |
| title_fullStr | Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study |
| title_full_unstemmed | Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study |
| title_short | Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study |
| title_sort | effect of anaesthetic agents on olfactory threshold and identification a single blinded randomised controlled study |
| topic | General anaesthesia neurotoxicity olfaction olfactory identification sevoflurane |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2018;volume=62;issue=8;spage=592;epage=598;aulast=Saravanan |
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