Topology Optimization of Passive Cell Traps
This paper discusses a flexible design method of cell traps based on the topology optimization of fluidic flows. Being different from the traditional method, this method obtains the periodic layout of the cell traps according to the cell trapping requirements by proposing a topology optimization mod...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/12/7/809 |
| _version_ | 1827687272271577088 |
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| author | Zhiqi Wang Yuchen Guo Eddie Wadbro Zhenyu Liu |
| author_facet | Zhiqi Wang Yuchen Guo Eddie Wadbro Zhenyu Liu |
| author_sort | Zhiqi Wang |
| collection | DOAJ |
| description | This paper discusses a flexible design method of cell traps based on the topology optimization of fluidic flows. Being different from the traditional method, this method obtains the periodic layout of the cell traps according to the cell trapping requirements by proposing a topology optimization model. Additionally, it satisfies the cell trapping function by restricting the flow distribution while taking into account the overall energy dissipation of the flow field. The dependence on the experience of the designer is reduced when this method is used to design a cell trap with acceptable trapping performance. By comparing the influence of the changes of various parameters on the optimization results, the flexibility of the topology optimization method for cell trap structure optimization is verified. The capability of this design method is validated by several performed comparisons between the obtained layouts and optimized designs in the published literature. |
| first_indexed | 2024-03-10T09:31:11Z |
| format | Article |
| id | doaj.art-1fab035af94c4f0f8c4c1bf276dc4f5c |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T09:31:11Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-1fab035af94c4f0f8c4c1bf276dc4f5c2023-11-22T04:24:52ZengMDPI AGMicromachines2072-666X2021-07-0112780910.3390/mi12070809Topology Optimization of Passive Cell TrapsZhiqi Wang0Yuchen Guo1Eddie Wadbro2Zhenyu Liu3Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Changchun 130033, ChinaJi Hua Laboratory, Foshan 528000, ChinaDepartment of Mathematics and Computer Science, Karlstad University, SE-651 88 Karlstad, SwedenChangchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Changchun 130033, ChinaThis paper discusses a flexible design method of cell traps based on the topology optimization of fluidic flows. Being different from the traditional method, this method obtains the periodic layout of the cell traps according to the cell trapping requirements by proposing a topology optimization model. Additionally, it satisfies the cell trapping function by restricting the flow distribution while taking into account the overall energy dissipation of the flow field. The dependence on the experience of the designer is reduced when this method is used to design a cell trap with acceptable trapping performance. By comparing the influence of the changes of various parameters on the optimization results, the flexibility of the topology optimization method for cell trap structure optimization is verified. The capability of this design method is validated by several performed comparisons between the obtained layouts and optimized designs in the published literature.https://www.mdpi.com/2072-666X/12/7/809topology optimizationcell captureflow distributionperiodic layout |
| spellingShingle | Zhiqi Wang Yuchen Guo Eddie Wadbro Zhenyu Liu Topology Optimization of Passive Cell Traps Micromachines topology optimization cell capture flow distribution periodic layout |
| title | Topology Optimization of Passive Cell Traps |
| title_full | Topology Optimization of Passive Cell Traps |
| title_fullStr | Topology Optimization of Passive Cell Traps |
| title_full_unstemmed | Topology Optimization of Passive Cell Traps |
| title_short | Topology Optimization of Passive Cell Traps |
| title_sort | topology optimization of passive cell traps |
| topic | topology optimization cell capture flow distribution periodic layout |
| url | https://www.mdpi.com/2072-666X/12/7/809 |
| work_keys_str_mv | AT zhiqiwang topologyoptimizationofpassivecelltraps AT yuchenguo topologyoptimizationofpassivecelltraps AT eddiewadbro topologyoptimizationofpassivecelltraps AT zhenyuliu topologyoptimizationofpassivecelltraps |