Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity
Abnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/5/1033 |
| _version_ | 1797501355599855616 |
|---|---|
| author | Francisco Algaba-Chueca Elsa Maymó-Masip Mónica Ballesteros Albert Guarque Alejandro Majali-Martínez Olga Freixes Núria Amigó Sonia Fernández-Veledo Joan Vendrell Ana Megía |
| author_facet | Francisco Algaba-Chueca Elsa Maymó-Masip Mónica Ballesteros Albert Guarque Alejandro Majali-Martínez Olga Freixes Núria Amigó Sonia Fernández-Veledo Joan Vendrell Ana Megía |
| author_sort | Francisco Algaba-Chueca |
| collection | DOAJ |
| description | Abnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance (NMR)-based approach to profile the umbilical cord serum lipoproteins. Two-dimensional diffusion-ordered 1H-NMR spectroscopy showed that size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to control (<i>n</i> = 74) and GDM (<i>n</i> = 62) mothers. Subsequent data stratification according to newborn birth-weight categories, i.e., small (<i>n</i> = 39), appropriate (<i>n</i> = 50) or large (<i>n</i> = 49) for gestational age (SGA, AGA and LGA, respectively), showed an interaction between GDM and birth-weight categories for intermediate-density lipoproteins (IDL)-cholesterol content and IDL- and low-density lipoproteins (LDL)-triglyceride content, and the number of medium very low-density lipoproteins (VLDL) and LDL particles specifically in AGA neonates. Moreover, in a 2-year follow-up study, we observed that small LDL particles were independently associated with offspring obesity at 2 years (<i>n</i> = 103). Collectively, our data demonstrate that GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, with AGA neonates born to GDM mothers displaying a profile more similar to that of adults with dyslipidemia. Furthermore, an altered fetal lipoprotein pattern was associated with the development of obesity at 2 years. |
| first_indexed | 2024-03-10T03:17:12Z |
| format | Article |
| id | doaj.art-1facf9d359574f339221c7b3fc324df9 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:17:12Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1facf9d359574f339221c7b3fc324df92023-11-23T10:10:04ZengMDPI AGBiomedicines2227-90592022-04-01105103310.3390/biomedicines10051033Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant ObesityFrancisco Algaba-Chueca0Elsa Maymó-Masip1Mónica Ballesteros2Albert Guarque3Alejandro Majali-Martínez4Olga Freixes5Núria Amigó6Sonia Fernández-Veledo7Joan Vendrell8Ana Megía9Department of Endocrinology and Nutrition and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV), Dr. Mallafre Guasch, 4, 43005 Tarragona, SpainDepartment of Endocrinology and Nutrition and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV), Dr. Mallafre Guasch, 4, 43005 Tarragona, SpainDepartament of Basic Medical Sciences and Department of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, SpainDepartament of Basic Medical Sciences and Department of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, SpainDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, AustriaDepartment of Endocrinology and Nutrition and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV), Dr. Mallafre Guasch, 4, 43005 Tarragona, SpainCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)—Instituto de Salud Carlos III, 28029 Madrid, SpainDepartment of Endocrinology and Nutrition and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV), Dr. Mallafre Guasch, 4, 43005 Tarragona, SpainDepartment of Endocrinology and Nutrition and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV), Dr. Mallafre Guasch, 4, 43005 Tarragona, SpainDepartment of Endocrinology and Nutrition and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV), Dr. Mallafre Guasch, 4, 43005 Tarragona, SpainAbnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance (NMR)-based approach to profile the umbilical cord serum lipoproteins. Two-dimensional diffusion-ordered 1H-NMR spectroscopy showed that size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to control (<i>n</i> = 74) and GDM (<i>n</i> = 62) mothers. Subsequent data stratification according to newborn birth-weight categories, i.e., small (<i>n</i> = 39), appropriate (<i>n</i> = 50) or large (<i>n</i> = 49) for gestational age (SGA, AGA and LGA, respectively), showed an interaction between GDM and birth-weight categories for intermediate-density lipoproteins (IDL)-cholesterol content and IDL- and low-density lipoproteins (LDL)-triglyceride content, and the number of medium very low-density lipoproteins (VLDL) and LDL particles specifically in AGA neonates. Moreover, in a 2-year follow-up study, we observed that small LDL particles were independently associated with offspring obesity at 2 years (<i>n</i> = 103). Collectively, our data demonstrate that GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, with AGA neonates born to GDM mothers displaying a profile more similar to that of adults with dyslipidemia. Furthermore, an altered fetal lipoprotein pattern was associated with the development of obesity at 2 years.https://www.mdpi.com/2227-9059/10/5/1033birth-weightgestational diabeteslipoprotein profileobesityfetal blood |
| spellingShingle | Francisco Algaba-Chueca Elsa Maymó-Masip Mónica Ballesteros Albert Guarque Alejandro Majali-Martínez Olga Freixes Núria Amigó Sonia Fernández-Veledo Joan Vendrell Ana Megía Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity Biomedicines birth-weight gestational diabetes lipoprotein profile obesity fetal blood |
| title | Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity |
| title_full | Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity |
| title_fullStr | Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity |
| title_full_unstemmed | Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity |
| title_short | Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity |
| title_sort | cord blood advanced lipoprotein testing reveals an interaction between gestational diabetes and birth weight and suggests a new early biomarker of infant obesity |
| topic | birth-weight gestational diabetes lipoprotein profile obesity fetal blood |
| url | https://www.mdpi.com/2227-9059/10/5/1033 |
| work_keys_str_mv | AT franciscoalgabachueca cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT elsamaymomasip cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT monicaballesteros cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT albertguarque cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT alejandromajalimartinez cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT olgafreixes cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT nuriaamigo cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT soniafernandezveledo cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT joanvendrell cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity AT anamegia cordbloodadvancedlipoproteintestingrevealsaninteractionbetweengestationaldiabetesandbirthweightandsuggestsanewearlybiomarkerofinfantobesity |