Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents
Context: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to heal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Neurological Sciences and Neurophysiology |
| Subjects: | |
| Online Access: | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=2;spage=90;epage=96;aulast=Tekgul |
| _version_ | 1818454267534508032 |
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| author | Hasan Tekgul Ulas Saz Muzaffer Polat Nurdan Tekgul Timur Kose |
| author_facet | Hasan Tekgul Ulas Saz Muzaffer Polat Nurdan Tekgul Timur Kose |
| author_sort | Hasan Tekgul |
| collection | DOAJ |
| description | Context: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean ± standard deviation age: 6.4 ± 1.2 years; range: 3.0–20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents. |
| first_indexed | 2024-12-14T21:52:10Z |
| format | Article |
| id | doaj.art-1fada05f22e74e6586e1576dbcae211e |
| institution | Directory Open Access Journal |
| issn | 2636-865X |
| language | English |
| last_indexed | 2024-12-14T21:52:10Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neurological Sciences and Neurophysiology |
| spelling | doaj.art-1fada05f22e74e6586e1576dbcae211e2022-12-21T22:46:12ZengWolters Kluwer Medknow PublicationsNeurological Sciences and Neurophysiology2636-865X2021-01-01382909610.4103/NSN.NSN_94_20Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and AdolescentsHasan TekgulUlas SazMuzaffer PolatNurdan TekgulTimur KoseContext: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean ± standard deviation age: 6.4 ± 1.2 years; range: 3.0–20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents.http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=2;spage=90;epage=96;aulast=Tekgulicentral motor conduction timecorticospinal pathwayslatency jumpingmotor evoked potentialstranscranial magnetic stimulation |
| spellingShingle | Hasan Tekgul Ulas Saz Muzaffer Polat Nurdan Tekgul Timur Kose Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents Neurological Sciences and Neurophysiology icentral motor conduction time corticospinal pathways latency jumping motor evoked potentials transcranial magnetic stimulation |
| title | Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
| title_full | Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
| title_fullStr | Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
| title_full_unstemmed | Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
| title_short | Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents |
| title_sort | normative values of transcranial magnetic stimulation evoked parameters for healthy developing children and adolescents |
| topic | icentral motor conduction time corticospinal pathways latency jumping motor evoked potentials transcranial magnetic stimulation |
| url | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=2;spage=90;epage=96;aulast=Tekgul |
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