Optimization of Tissue Digestion Methods for Characterization of Photoaged Skin by Single Cell RNA Sequencing Reveals Preferential Enrichment of T Cell Subsets

Optimization of Tissue Digestion Methods for Characterization of Photoaged Skin by Single Cell RNA Sequencing Reveals Preferential Enrichment of T Cell Subsets

Healthy human skin tissue is often used as a control for comparison to diseased skin in patients with skin pathologies, including skin cancers or other inflammatory conditions such as atopic dermatitis or psoriasis. Although non-affected skin from these patients is a more appropriate choice for comp...

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Bibliographic Details
Main Authors: Terri Clister, Rosalyn M. Fey, Zachary R. Garrison, Cristian D. Valenzuela, Anna Bar, Justin J. Leitenberger, Rajan P. Kulkarni
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
tissue digestion
scRNA-seq
skin cancer
melanoma
immune cell composition
T cells
Online Access:https://www.mdpi.com/2073-4409/13/3/266

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