The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health
The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3253 |
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| author | Clarisse Roblin Steve Chiumento Cédric Jacqueline Eric Pinloche Cendrine Nicoletti Hamza Olleik Elise Courvoisier-Dezord Agnès Amouric Christian Basset Louis Dru Marie Ollivier Aurélie Bogey-Lambert Nicolas Vidal Mohamed Atta Marc Maresca Estelle Devillard Victor Duarte Josette Perrier Mickael Lafond |
| author_facet | Clarisse Roblin Steve Chiumento Cédric Jacqueline Eric Pinloche Cendrine Nicoletti Hamza Olleik Elise Courvoisier-Dezord Agnès Amouric Christian Basset Louis Dru Marie Ollivier Aurélie Bogey-Lambert Nicolas Vidal Mohamed Atta Marc Maresca Estelle Devillard Victor Duarte Josette Perrier Mickael Lafond |
| author_sort | Clarisse Roblin |
| collection | DOAJ |
| description | The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from <i>Clostridium perfringens</i> with a lower dose than the conventional antibiotic vancomycin. Moreover, antimicrobial peptide (AMP) is also effective against this pathogen in the complex microbial community of the gut environment, with a selective impact on a few bacterial genera, while maintaining a global homeostasis of the microbiome. In addition, ruminococcin C1 exhibits other biological activities that could be beneficial for human health, as well as other fields of applications. Overall, this study, by using an in vivo infection approach, confirms the antimicrobial clinical potential and highlights the multiple functional properties of ruminococcin C1, thus extending its therapeutic interest. |
| first_indexed | 2024-03-10T12:59:44Z |
| format | Article |
| id | doaj.art-1faf28a4c2f94be49d9b614ecd83a1b8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:59:44Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1faf28a4c2f94be49d9b614ecd83a1b82023-11-21T11:37:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226325310.3390/ijms22063253The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human HealthClarisse Roblin0Steve Chiumento1Cédric Jacqueline2Eric Pinloche3Cendrine Nicoletti4Hamza Olleik5Elise Courvoisier-Dezord6Agnès Amouric7Christian Basset8Louis Dru9Marie Ollivier10Aurélie Bogey-Lambert11Nicolas Vidal12Mohamed Atta13Marc Maresca14Estelle Devillard15Victor Duarte16Josette Perrier17Mickael Lafond18CNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceUniversity Grenoble Alpes, CEA, IRIG, CBM, CNRS UMR5249, 38054 Grenoble, FranceEA3826, IRS2 Nantes-Biotech, Université de Nantes, 44200 Nantes, FranceCentre d’Expertise et de Recherche en Nutrition, ADISSEO France SAS, 03600 Commentry, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceUniversity Grenoble Alpes, CEA, IRIG, CBM, CNRS UMR5249, 38054 Grenoble, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceBioAzur Biogroup-Vet’Analys Laboratory, 83400 Hyères, FranceBioAzur Biogroup-Vet’Analys Laboratory, 83400 Hyères, FranceYelen Analytics, Aix-Marseille University ICR, 13013 Marseille, FranceUniversity Grenoble Alpes, CEA, IRIG, CBM, CNRS UMR5249, 38054 Grenoble, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceCentre d’Expertise et de Recherche en Nutrition, ADISSEO France SAS, 03600 Commentry, FranceUniversity Grenoble Alpes, CEA, IRIG, CBM, CNRS UMR5249, 38054 Grenoble, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceCNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, FranceThe world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from <i>Clostridium perfringens</i> with a lower dose than the conventional antibiotic vancomycin. Moreover, antimicrobial peptide (AMP) is also effective against this pathogen in the complex microbial community of the gut environment, with a selective impact on a few bacterial genera, while maintaining a global homeostasis of the microbiome. In addition, ruminococcin C1 exhibits other biological activities that could be beneficial for human health, as well as other fields of applications. Overall, this study, by using an in vivo infection approach, confirms the antimicrobial clinical potential and highlights the multiple functional properties of ruminococcin C1, thus extending its therapeutic interest.https://www.mdpi.com/1422-0067/22/6/3253antibioticsantimicrobial resistanceRiPPsactipeptide<i>Ruminococcus gnavus</i> E1peritonitis infection |
| spellingShingle | Clarisse Roblin Steve Chiumento Cédric Jacqueline Eric Pinloche Cendrine Nicoletti Hamza Olleik Elise Courvoisier-Dezord Agnès Amouric Christian Basset Louis Dru Marie Ollivier Aurélie Bogey-Lambert Nicolas Vidal Mohamed Atta Marc Maresca Estelle Devillard Victor Duarte Josette Perrier Mickael Lafond The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health International Journal of Molecular Sciences antibiotics antimicrobial resistance RiPP sactipeptide <i>Ruminococcus gnavus</i> E1 peritonitis infection |
| title | The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health |
| title_full | The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health |
| title_fullStr | The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health |
| title_full_unstemmed | The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health |
| title_short | The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health |
| title_sort | multifunctional sactipeptide ruminococcin c1 displays potent antibacterial activity in vivo as well as other beneficial properties for human health |
| topic | antibiotics antimicrobial resistance RiPP sactipeptide <i>Ruminococcus gnavus</i> E1 peritonitis infection |
| url | https://www.mdpi.com/1422-0067/22/6/3253 |
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