Blood transcriptome based biomarkers for human circadian phase

Blood transcriptome based biomarkers for human circadian phase

Diagnosis and treatment of circadian rhythm sleep-wake disorders both require assessment of circadian phase of the brain’s circadian pacemaker. The gold-standard univariate method is based on collection of a 24-hr time series of plasma melatonin, a suprachiasmatic nucleus-driven pineal hormone. We d...

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Bibliographic Details
Main Authors: Emma E Laing, Carla S Möller-Levet, Norman Poh, Nayantara Santhi, Simon N Archer, Derk-Jan Dijk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
biomarker
transcriptomics
machine learning
sleep disorders
neurodegeneration
chronotherapy
Online Access:https://elifesciences.org/articles/20214

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