Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures
In bladder cancer, urothelial carcinoma is the most common histologic subtype, accounting for more than 90% of cases. Pathogenic effects due to the dysbiosis of gut microbiota are localized not only in the colon, but also in regulating bladder cancer distally. Butyrate, a short-chain fatty acid prod...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2270 |
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| author | Yen-Chieh Wang Wei-Chi Ku Chih-Yi Liu Yu-Che Cheng Chih-Cheng Chien Kang-Wei Chang Chi-Jung Huang |
| author_facet | Yen-Chieh Wang Wei-Chi Ku Chih-Yi Liu Yu-Che Cheng Chih-Cheng Chien Kang-Wei Chang Chi-Jung Huang |
| author_sort | Yen-Chieh Wang |
| collection | DOAJ |
| description | In bladder cancer, urothelial carcinoma is the most common histologic subtype, accounting for more than 90% of cases. Pathogenic effects due to the dysbiosis of gut microbiota are localized not only in the colon, but also in regulating bladder cancer distally. Butyrate, a short-chain fatty acid produced by gut microbial metabolism, is mainly studied in colon diseases. Therefore, the resolution of the anti-cancer effects of butyrate-producing microbes on bladder urothelial cells and knowledge of the butyrate-responsive molecules must have clinical significance. Here, we demonstrate a correlation between urothelial cancer of the bladder and <i>Butyricicoccus pullicaecorum</i>. This butyrate-producing microbe or their metabolite, butyrate, mediated anti-cancer effects on bladder urothelial cells by regulating cell cycle, cell growth, apoptosis, and gene expression. For example, a tumor suppressor against urothelial cancer of the bladder, bladder cancer-associated protein, was induced in butyrate-treated HT1376 cells, a human urinary bladder cancer cell line. In conclusion, urothelial cancer of the bladder is a significant health problem. To improve the health of bladder urothelial cells, supplementation of <i>B. pullicaecorum</i> may be necessary and can further regulate butyrate-responsive molecular signatures. |
| first_indexed | 2024-03-10T04:18:41Z |
| format | Article |
| id | doaj.art-1fb17735239c46d3b935abb248217b28 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:18:41Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1fb17735239c46d3b935abb248217b282023-11-23T07:53:45ZengMDPI AGDiagnostics2075-44182021-12-011112227010.3390/diagnostics11122270Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular SignaturesYen-Chieh Wang0Wei-Chi Ku1Chih-Yi Liu2Yu-Che Cheng3Chih-Cheng Chien4Kang-Wei Chang5Chi-Jung Huang6Department of Urology, Cathay General Hospital, Taipei 106438, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242062, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242062, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242062, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242062, TaiwanTaipei Neuroscience Institute, Taipei Medical University, Taipei 110301, TaiwanDepartment of Medical Research, Cathay General Hospital, Taipei 106438, TaiwanIn bladder cancer, urothelial carcinoma is the most common histologic subtype, accounting for more than 90% of cases. Pathogenic effects due to the dysbiosis of gut microbiota are localized not only in the colon, but also in regulating bladder cancer distally. Butyrate, a short-chain fatty acid produced by gut microbial metabolism, is mainly studied in colon diseases. Therefore, the resolution of the anti-cancer effects of butyrate-producing microbes on bladder urothelial cells and knowledge of the butyrate-responsive molecules must have clinical significance. Here, we demonstrate a correlation between urothelial cancer of the bladder and <i>Butyricicoccus pullicaecorum</i>. This butyrate-producing microbe or their metabolite, butyrate, mediated anti-cancer effects on bladder urothelial cells by regulating cell cycle, cell growth, apoptosis, and gene expression. For example, a tumor suppressor against urothelial cancer of the bladder, bladder cancer-associated protein, was induced in butyrate-treated HT1376 cells, a human urinary bladder cancer cell line. In conclusion, urothelial cancer of the bladder is a significant health problem. To improve the health of bladder urothelial cells, supplementation of <i>B. pullicaecorum</i> may be necessary and can further regulate butyrate-responsive molecular signatures.https://www.mdpi.com/2075-4418/11/12/2270urothelial bladder cancerbutyrate<i>Butyricicoccus pullicaecorum</i>apoptosisbladder cancer-associated protein |
| spellingShingle | Yen-Chieh Wang Wei-Chi Ku Chih-Yi Liu Yu-Che Cheng Chih-Cheng Chien Kang-Wei Chang Chi-Jung Huang Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures Diagnostics urothelial bladder cancer butyrate <i>Butyricicoccus pullicaecorum</i> apoptosis bladder cancer-associated protein |
| title | Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures |
| title_full | Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures |
| title_fullStr | Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures |
| title_full_unstemmed | Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures |
| title_short | Supplementation of Probiotic <i>Butyricicoccus pullicaecorum</i> Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures |
| title_sort | supplementation of probiotic i butyricicoccus pullicaecorum i mediates anticancer effect on bladder urothelial cells by regulating butyrate responsive molecular signatures |
| topic | urothelial bladder cancer butyrate <i>Butyricicoccus pullicaecorum</i> apoptosis bladder cancer-associated protein |
| url | https://www.mdpi.com/2075-4418/11/12/2270 |
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