Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital.
<h4>Introduction</h4>Evidence implicates vitamin D deficiency in poorer outcomes and increased susceptibility to hospital-acquired infections (HAIs). This study examined the association between serum vitamin D levels and HAIs in a population of hepatobiliary surgery patients.<h4>Me...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0230336 |
| _version_ | 1818591054385905664 |
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| author | Estefania Laviano Maria Sanchez Rubio Maria Teresa González-Nicolás María Pilar Palacian Javier López Yolanda Gilaberte Pilar Calmarza Antonio Rezusta Alejandro Serrablo |
| author_facet | Estefania Laviano Maria Sanchez Rubio Maria Teresa González-Nicolás María Pilar Palacian Javier López Yolanda Gilaberte Pilar Calmarza Antonio Rezusta Alejandro Serrablo |
| author_sort | Estefania Laviano |
| collection | DOAJ |
| description | <h4>Introduction</h4>Evidence implicates vitamin D deficiency in poorer outcomes and increased susceptibility to hospital-acquired infections (HAIs). This study examined the association between serum vitamin D levels and HAIs in a population of hepatobiliary surgery patients.<h4>Methods</h4>Participants in this prospective analytical observational study were patients who underwent hepatobiliary surgery in a tertiary hospital in Aragon, Spain, between February 2018 and March 2019. Vitamin D concentrations were measured at admission and all nosocomial infections during hospitalization and after discharge were recorded.<h4>Results</h4>The mean 25-hydroxyvitamin D concentration of the study population (n = 301) was 38.56 nmol/L, which corresponds to vitamin D deficiency. Higher vitamin D concentrations were associated with a decreased likelihood of developing a HAI in general (p = 0.014), and in particularly surgical site infection (p = 0.026). The risk of HAI decreased by 34% with each 26.2-nmol/L increase in serum vitamin D levels.<h4>Conclusions</h4>Vitamin D levels may constitute a modifiable risk factor for postoperative nosocomial infections in hepatobiliary surgery patients. |
| first_indexed | 2024-12-16T10:06:20Z |
| format | Article |
| id | doaj.art-1fb408571f8949d3bbc3f8b578cd8536 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T10:06:20Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1fb408571f8949d3bbc3f8b578cd85362022-12-21T22:35:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01153e023033610.1371/journal.pone.0230336Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital.Estefania LavianoMaria Sanchez RubioMaria Teresa González-NicolásMaría Pilar PalacianJavier LópezYolanda GilabertePilar CalmarzaAntonio RezustaAlejandro Serrablo<h4>Introduction</h4>Evidence implicates vitamin D deficiency in poorer outcomes and increased susceptibility to hospital-acquired infections (HAIs). This study examined the association between serum vitamin D levels and HAIs in a population of hepatobiliary surgery patients.<h4>Methods</h4>Participants in this prospective analytical observational study were patients who underwent hepatobiliary surgery in a tertiary hospital in Aragon, Spain, between February 2018 and March 2019. Vitamin D concentrations were measured at admission and all nosocomial infections during hospitalization and after discharge were recorded.<h4>Results</h4>The mean 25-hydroxyvitamin D concentration of the study population (n = 301) was 38.56 nmol/L, which corresponds to vitamin D deficiency. Higher vitamin D concentrations were associated with a decreased likelihood of developing a HAI in general (p = 0.014), and in particularly surgical site infection (p = 0.026). The risk of HAI decreased by 34% with each 26.2-nmol/L increase in serum vitamin D levels.<h4>Conclusions</h4>Vitamin D levels may constitute a modifiable risk factor for postoperative nosocomial infections in hepatobiliary surgery patients.https://doi.org/10.1371/journal.pone.0230336 |
| spellingShingle | Estefania Laviano Maria Sanchez Rubio Maria Teresa González-Nicolás María Pilar Palacian Javier López Yolanda Gilaberte Pilar Calmarza Antonio Rezusta Alejandro Serrablo Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital. PLoS ONE |
| title | Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital. |
| title_full | Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital. |
| title_fullStr | Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital. |
| title_full_unstemmed | Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital. |
| title_short | Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital. |
| title_sort | association between preoperative levels of 25 hydroxyvitamin d and hospital acquired infections after hepatobiliary surgery a prospective study in a third level hospital |
| url | https://doi.org/10.1371/journal.pone.0230336 |
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