Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography
Abstract Objectives The endometrium of most unexplained infertility (UI) patients has been altered histologically. Shear wave elastography (SWE) is utilized to assess the signature of living tissue. This study aimed to explore the value of SWE in evaluating endometrial receptivity (ER) in UI patient...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-03-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-024-01646-3 |
| _version_ | 1797247181227294720 |
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| author | Zheng-ying Li Lu Cai Zhi-jun Zhang Hai-rong Zou Mei He Mei-lin Qin Hui Wang |
| author_facet | Zheng-ying Li Lu Cai Zhi-jun Zhang Hai-rong Zou Mei He Mei-lin Qin Hui Wang |
| author_sort | Zheng-ying Li |
| collection | DOAJ |
| description | Abstract Objectives The endometrium of most unexplained infertility (UI) patients has been altered histologically. Shear wave elastography (SWE) is utilized to assess the signature of living tissue. This study aimed to explore the value of SWE in evaluating endometrial receptivity (ER) in UI patients. Methods In total, 59 UI patients (UI group) and 52 normal control women (NC group) who received fertility consultation in our hospital were included between January 2022 and June 2023. We divided them into the late-proliferative phase of UI group (LPUI; n = 59), mid-secretory phase of UI group (MPUI; n = 41), late-proliferative phase of NC group (LPNC; n = 52), and mid-secretory phase of NC group (MPNC; n = 45). Transvaginal ultrasonography and SWE were performed during the LP and MP. Endometrial thickness (EMT), uterine artery pulsatility index (UA-PI), endometrial mean elasticity (E-mean), and mean shear wave velocities (SWV-mean) were measured. Results There were significant differences in E-mean, SWV-mean, EMT, and UA-PI between the UI group and the NC group during both the LP and MP (p MPNC vs MPUI < 0.05, p LPNC vs LPUI < 0.05). E-mean and SWV-mean decreased with increasing EMT but increased with increasing UA-PI (p < 0.05). The most effective parameter for evaluating ER in UI patients is the E-mean (AUC = 0.89). Conclusions UI patients exhibited thinner endometrium, increased endometrial stiffness, and poor endometrial blood perfusion. E-mean was the most effective parameter to evaluate ER in UI patients. The study preliminarily proved that SWE is a promising non-invasive tool for evaluating the condition of endometrium. Critical relevance statement This study aimed to explore the significance of endometrial elasticity measured by SWE in evaluating patients with UI. The findings revealed a correlation between EMT, UA-PI, and E-mean. Endometrial elasticity can serve as an effective indicator for predicting ER. Key points 1. To explore the significance of endometrial elasticity in assessing patients with UI. 2. The endometrium of UI patient exhibited thinness, stiffness, and poor blood perfusion. 3. Endometrial elasticity serves as a valuable indicator for evaluating endometrial receptivity. Graphical Abstract |
| first_indexed | 2024-04-24T19:54:36Z |
| format | Article |
| id | doaj.art-1fb42e21cd0f49d6a387988381c0f576 |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-04-24T19:54:36Z |
| publishDate | 2024-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-1fb42e21cd0f49d6a387988381c0f5762024-03-24T12:22:56ZengSpringerOpenInsights into Imaging1869-41012024-03-0115111010.1186/s13244-024-01646-3Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastographyZheng-ying Li0Lu Cai1Zhi-jun Zhang2Hai-rong Zou3Mei He4Mei-lin Qin5Hui Wang6Department of Ultrasound, University-Town Hospital of Chongqing Medical UniversityDepartment of Ultrasound, University-Town Hospital of Chongqing Medical UniversityDepartment of Ultrasound, University-Town Hospital of Chongqing Medical UniversityDepartment of Ultrasound, University-Town Hospital of Chongqing Medical UniversityDepartment of Ultrasound, University-Town Hospital of Chongqing Medical UniversityDepartment of Ultrasound, University-Town Hospital of Chongqing Medical UniversityDepartment of Ultrasound, University-Town Hospital of Chongqing Medical UniversityAbstract Objectives The endometrium of most unexplained infertility (UI) patients has been altered histologically. Shear wave elastography (SWE) is utilized to assess the signature of living tissue. This study aimed to explore the value of SWE in evaluating endometrial receptivity (ER) in UI patients. Methods In total, 59 UI patients (UI group) and 52 normal control women (NC group) who received fertility consultation in our hospital were included between January 2022 and June 2023. We divided them into the late-proliferative phase of UI group (LPUI; n = 59), mid-secretory phase of UI group (MPUI; n = 41), late-proliferative phase of NC group (LPNC; n = 52), and mid-secretory phase of NC group (MPNC; n = 45). Transvaginal ultrasonography and SWE were performed during the LP and MP. Endometrial thickness (EMT), uterine artery pulsatility index (UA-PI), endometrial mean elasticity (E-mean), and mean shear wave velocities (SWV-mean) were measured. Results There were significant differences in E-mean, SWV-mean, EMT, and UA-PI between the UI group and the NC group during both the LP and MP (p MPNC vs MPUI < 0.05, p LPNC vs LPUI < 0.05). E-mean and SWV-mean decreased with increasing EMT but increased with increasing UA-PI (p < 0.05). The most effective parameter for evaluating ER in UI patients is the E-mean (AUC = 0.89). Conclusions UI patients exhibited thinner endometrium, increased endometrial stiffness, and poor endometrial blood perfusion. E-mean was the most effective parameter to evaluate ER in UI patients. The study preliminarily proved that SWE is a promising non-invasive tool for evaluating the condition of endometrium. Critical relevance statement This study aimed to explore the significance of endometrial elasticity measured by SWE in evaluating patients with UI. The findings revealed a correlation between EMT, UA-PI, and E-mean. Endometrial elasticity can serve as an effective indicator for predicting ER. Key points 1. To explore the significance of endometrial elasticity in assessing patients with UI. 2. The endometrium of UI patient exhibited thinness, stiffness, and poor blood perfusion. 3. Endometrial elasticity serves as a valuable indicator for evaluating endometrial receptivity. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01646-3Endometrial receptivityEndometriumElasticityShear wave elastographyUnexplained infertility |
| spellingShingle | Zheng-ying Li Lu Cai Zhi-jun Zhang Hai-rong Zou Mei He Mei-lin Qin Hui Wang Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography Insights into Imaging Endometrial receptivity Endometrium Elasticity Shear wave elastography Unexplained infertility |
| title | Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography |
| title_full | Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography |
| title_fullStr | Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography |
| title_full_unstemmed | Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography |
| title_short | Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography |
| title_sort | evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography |
| topic | Endometrial receptivity Endometrium Elasticity Shear wave elastography Unexplained infertility |
| url | https://doi.org/10.1186/s13244-024-01646-3 |
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