Synthesis of Cystine-Stabilised Dicarba Conotoxin EpI: Ring-Closing Metathesis of Sidechain Deprotected, Sulfide-Rich Sequences

Synthesis of Cystine-Stabilised Dicarba Conotoxin EpI: Ring-Closing Metathesis of Sidechain Deprotected, Sulfide-Rich Sequences

Recombinant peptide synthesis allows for large-scale production of peptides with therapeutic potential. However, access to dicarba peptidomimetics via sidechain-deprotected sequences becomes challenging with exposed Lewis basicity presented by amine and sulfur-containing residues. Presented here is...

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Bibliographic Details
Main Authors: Amy L. Thomson, Andrea J. Robinson, Alessia Belgi
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Marine Drugs
Subjects:
olefin metathesis
cysteine
methionine
disulfide replacement
unprotected peptides
dicarba peptides
Online Access:https://www.mdpi.com/1660-3397/21/7/390

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