STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages
Summary: The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function of tumor-associated macrophages is a potential therapeutic strategy to control tumor metastasis. We found in vivo exp...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223014530 |
| _version_ | 1797770031642181632 |
|---|---|
| author | Yixuan Liu Qi Sun Chengfei Zhang Min Ding Cheng Wang Qian Zheng Zhijie Ma Haojun Xu Guoren Zhou Xiaoming Wang Zhangjun Cheng Hongping Xia |
| author_facet | Yixuan Liu Qi Sun Chengfei Zhang Min Ding Cheng Wang Qian Zheng Zhijie Ma Haojun Xu Guoren Zhou Xiaoming Wang Zhangjun Cheng Hongping Xia |
| author_sort | Yixuan Liu |
| collection | DOAJ |
| description | Summary: The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function of tumor-associated macrophages is a potential therapeutic strategy to control tumor metastasis. We found in vivo experiments that the activation of STING inhibited CRC liver metastasis in model mice and affected the macrophage phenotype in the tumor microenvironment. Mechanistically, STING affects TAM polarization and regulates macrophage function through IRG1. And STING activates IRG1 to promote the nuclear translocation of TFEB, affecting the ability of macrophages to suppress tumor metastasis.Therefore, this study highlights the critical role of the STING-IRG1 axis on TAM reprogramming and its role in the process of tumor liver metastasis, which may provide a promising therapeutic strategy for CRC liver metastasis. |
| first_indexed | 2024-03-12T21:17:32Z |
| format | Article |
| id | doaj.art-1fb5d7b6096d4129bd91b1a7c2a7eb59 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T21:17:32Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-1fb5d7b6096d4129bd91b1a7c2a7eb592023-07-29T04:35:44ZengElsevieriScience2589-00422023-08-01268107376STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophagesYixuan Liu0Qi Sun1Chengfei Zhang2Min Ding3Cheng Wang4Qian Zheng5Zhijie Ma6Haojun Xu7Guoren Zhou8Xiaoming Wang9Zhangjun Cheng10Hongping Xia11Department of Pathology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China; Hepato-Pancreato-Biliary Center, Zhongda Hospital, School of Medicine & Advanced Institute for Life and Health, Southeast University, Nanjing 210009, China; School of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Pathology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China; Hepato-Pancreato-Biliary Center, Zhongda Hospital, School of Medicine & Advanced Institute for Life and Health, Southeast University, Nanjing 210009, China; School of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, ChinaSir Run Run Hospital, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710072, ChinaSchool of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, ChinaSchool of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, ChinaSchool of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, ChinaSchool of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, ChinaJiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing 210009, China; Corresponding authorDepartment of Hepato-Biliary-Pancreatic Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, China; Corresponding authorHepato-Pancreato-Biliary Center, Zhongda Hospital, School of Medicine & Advanced Institute for Life and Health, Southeast University, Nanjing 210009, China; Corresponding authorDepartment of Pathology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China; Hepato-Pancreato-Biliary Center, Zhongda Hospital, School of Medicine & Advanced Institute for Life and Health, Southeast University, Nanjing 210009, China; School of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing 211166, China; Corresponding authorSummary: The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function of tumor-associated macrophages is a potential therapeutic strategy to control tumor metastasis. We found in vivo experiments that the activation of STING inhibited CRC liver metastasis in model mice and affected the macrophage phenotype in the tumor microenvironment. Mechanistically, STING affects TAM polarization and regulates macrophage function through IRG1. And STING activates IRG1 to promote the nuclear translocation of TFEB, affecting the ability of macrophages to suppress tumor metastasis.Therefore, this study highlights the critical role of the STING-IRG1 axis on TAM reprogramming and its role in the process of tumor liver metastasis, which may provide a promising therapeutic strategy for CRC liver metastasis.http://www.sciencedirect.com/science/article/pii/S2589004223014530Biological sciencesmolecular biologyImmunitycancer |
| spellingShingle | Yixuan Liu Qi Sun Chengfei Zhang Min Ding Cheng Wang Qian Zheng Zhijie Ma Haojun Xu Guoren Zhou Xiaoming Wang Zhangjun Cheng Hongping Xia STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages iScience Biological sciences molecular biology Immunity cancer |
| title | STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages |
| title_full | STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages |
| title_fullStr | STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages |
| title_full_unstemmed | STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages |
| title_short | STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages |
| title_sort | sting irg1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor associated macrophages |
| topic | Biological sciences molecular biology Immunity cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223014530 |
| work_keys_str_mv | AT yixuanliu stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT qisun stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT chengfeizhang stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT minding stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT chengwang stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT qianzheng stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT zhijiema stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT haojunxu stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT guorenzhou stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT xiaomingwang stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT zhangjuncheng stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages AT hongpingxia stingirg1inhibitslivermetastasisofcolorectalcancerbyregulatingthepolarizationoftumorassociatedmacrophages |