Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion
Misfolded SOD1 has been linked to both familial and sporadic ALS. Here the authors have determined the cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 from its immature form into an aggregated form during pathogenesis of ALS.
Bibliographic Details
| Main Authors: |
Li-Qiang Wang,
Yeyang Ma,
Han-Ye Yuan,
Kun Zhao,
Mu-Ya Zhang,
Qiang Wang,
Xi Huang,
Wen-Chang Xu,
Bin Dai,
Jie Chen,
Dan Li,
Delin Zhang,
Zhengzhi Wang,
Liangyu Zou,
Ping Yin,
Cong Liu,
Yi Liang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31240-4
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