Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB.

Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB.

The KIX domain of CBP is a transcriptional coactivator. Concomitant binding to the activation domain of proto-oncogene protein c-Myb and the transactivation domain of the trithorax group protein mixed lineage leukemia (MLL) transcription factor lead to the biologically active ternary MLL∶KIX∶c-Myb c...

Full description

Bibliographic Details
Main Authors: Elif Nihal Korkmaz, Ruth Nussinov, Türkan Haliloğlu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3305381?pdf=render

Similar Items

Similar Items