Factors involved in the design of nasal delivery systems for peptides and proteins
Because the nasal mucous is one of the most permeable areas, the intranasal delivery route is the most promising for proteins and peptides to reach the central nervous system (CNS). Nevertheless certain aspects of these macromolecules limit their bioavailability, such as molecular weight, the rapid...
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| Format: | Article |
| Language: | English |
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Elfos Scientiae
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| Series: | Biotecnología Aplicada |
| Subjects: | |
| Online Access: | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522013000200001&lng=en&tlng=en |
| _version_ | 1819295160116183040 |
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| author | Adriana Muñoz-Cernada Mirna Fernández-Cervera Julio César García-Rodríguez |
| author_facet | Adriana Muñoz-Cernada Mirna Fernández-Cervera Julio César García-Rodríguez |
| author_sort | Adriana Muñoz-Cernada |
| collection | DOAJ |
| description | Because the nasal mucous is one of the most permeable areas, the intranasal delivery route is the most promising for proteins and peptides to reach the central nervous system (CNS). Nevertheless certain aspects of these macromolecules limit their bioavailability, such as molecular weight, the rapid mucociliary clearance mechanism and enzymatic degradation. This paper critically summarizes the factors participating in the design of systems for the nasal delivery of peptides and proteins. The physicochemical properties of the biomolecules and features of the formulation design that directly influence their bioavailablity and stability are presented. Pharmaceutical aspects include an analysis of the influence of excipients that act as stabilizers, antimicrobial preservatives, absorption enhancers, and bioadhesive polymers as well as the administration device. The use of molecules involved in endogenous neuroprotection administered intranasally is a recent proposal in the development of new drugs. Neurotrophic factors, interferon beta-1b, erithropietin (i.e.: rH-EPO, Neuro-EPO) and insulin, are among the biotechnology products administered intranasally. These new products show greater therapeutic potential as putative neuroprotectors in neurological diseases, both for treatment during the acute phase, and for the chronic stage. |
| first_indexed | 2024-12-24T04:37:48Z |
| format | Article |
| id | doaj.art-1fb6f6a370d94e32b6f550d84703e553 |
| institution | Directory Open Access Journal |
| issn | 1027-2852 |
| language | English |
| last_indexed | 2024-12-24T04:37:48Z |
| publisher | Elfos Scientiae |
| record_format | Article |
| series | Biotecnología Aplicada |
| spelling | doaj.art-1fb6f6a370d94e32b6f550d84703e5532022-12-21T17:15:01ZengElfos ScientiaeBiotecnología Aplicada1027-28523028896S1027-28522013000200001Factors involved in the design of nasal delivery systems for peptides and proteinsAdriana Muñoz-Cernada0Mirna Fernández-Cervera1Julio César García-Rodríguez2Centro de Investigación y Desarrollo de Medicamentos, CidemUniversidad de La Habana, UHComité Ejecutivo del Consejo de MinistrosBecause the nasal mucous is one of the most permeable areas, the intranasal delivery route is the most promising for proteins and peptides to reach the central nervous system (CNS). Nevertheless certain aspects of these macromolecules limit their bioavailability, such as molecular weight, the rapid mucociliary clearance mechanism and enzymatic degradation. This paper critically summarizes the factors participating in the design of systems for the nasal delivery of peptides and proteins. The physicochemical properties of the biomolecules and features of the formulation design that directly influence their bioavailablity and stability are presented. Pharmaceutical aspects include an analysis of the influence of excipients that act as stabilizers, antimicrobial preservatives, absorption enhancers, and bioadhesive polymers as well as the administration device. The use of molecules involved in endogenous neuroprotection administered intranasally is a recent proposal in the development of new drugs. Neurotrophic factors, interferon beta-1b, erithropietin (i.e.: rH-EPO, Neuro-EPO) and insulin, are among the biotechnology products administered intranasally. These new products show greater therapeutic potential as putative neuroprotectors in neurological diseases, both for treatment during the acute phase, and for the chronic stage.http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522013000200001&lng=en&tlng=enintranasal deliverypeptidesproteinsexcipientsformulationneuroprotection |
| spellingShingle | Adriana Muñoz-Cernada Mirna Fernández-Cervera Julio César García-Rodríguez Factors involved in the design of nasal delivery systems for peptides and proteins Biotecnología Aplicada intranasal delivery peptides proteins excipients formulation neuroprotection |
| title | Factors involved in the design of nasal delivery systems for peptides and proteins |
| title_full | Factors involved in the design of nasal delivery systems for peptides and proteins |
| title_fullStr | Factors involved in the design of nasal delivery systems for peptides and proteins |
| title_full_unstemmed | Factors involved in the design of nasal delivery systems for peptides and proteins |
| title_short | Factors involved in the design of nasal delivery systems for peptides and proteins |
| title_sort | factors involved in the design of nasal delivery systems for peptides and proteins |
| topic | intranasal delivery peptides proteins excipients formulation neuroprotection |
| url | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522013000200001&lng=en&tlng=en |
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