Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents
This study is the first to identify the effects of FTO genotype on the interactions between the level of macro-nutrients intake and the expression level of fat mass and obesity associated (FTO) and homeobox transcription factor iriquois-3 (IRX3) genes This longitudinal study was carried out on 84 ov...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Adipocyte |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21623945.2019.1693745 |
| _version_ | 1818314747470151680 |
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| author | Saeid Doaei Naser Kalantari Pantea Izadi Tuire Salonurmi Alireza Mosavi Jarrahi Shahram Rafieifar Ghasem Azizi Tabesh Ghazaleh Rahimzadeh Maryam Gholamalizadeh Mark O. Goodarzi |
| author_facet | Saeid Doaei Naser Kalantari Pantea Izadi Tuire Salonurmi Alireza Mosavi Jarrahi Shahram Rafieifar Ghasem Azizi Tabesh Ghazaleh Rahimzadeh Maryam Gholamalizadeh Mark O. Goodarzi |
| author_sort | Saeid Doaei |
| collection | DOAJ |
| description | This study is the first to identify the effects of FTO genotype on the interactions between the level of macro-nutrients intake and the expression level of fat mass and obesity associated (FTO) and homeobox transcription factor iriquois-3 (IRX3) genes This longitudinal study was carried out on 84 overweight and obese adolescent boys in Tehran, Iran. The rs9930506 SNP in FTO was genotyped at baseline and the level of FTO and IRX3 expression in PBMCs and macro-nutrients’ intake were assessed at baseline and after 18 weeks of the intervention. The results identified that the higher carbohydrates intake significantly up-regulated the FTO gene (P = 0.001) and down-regulated the IRX3 gene (P = 0.01). Protein intake up-regulated the FTO gene (P = 0.001). In carriers of GG genotype of FTO gene, the amount of dietary carbohydrate had a positive association with FTO gene expression (p = 0.001, and p = 0.04, respectively). In AA/AG carriers, dietary protein was positively associated with FTO gene expression (p = 0.001) and dietary carbohydrate was negatively associated with IRX3 gene expression (P = 0.04). Therefore, dietary carbohydrateseems to be associated with FTO and IRX3 genes expression. These associations are influenced by FTO genotype. |
| first_indexed | 2024-12-13T08:54:33Z |
| format | Article |
| id | doaj.art-1fb859f42e914b2085cbf38e08d9dca6 |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-12-13T08:54:33Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-1fb859f42e914b2085cbf38e08d9dca62022-12-21T23:53:19ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2019-01-018138639110.1080/21623945.2019.16937451693745Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescentsSaeid Doaei0Naser Kalantari1Pantea Izadi2Tuire Salonurmi3Alireza Mosavi Jarrahi4Shahram Rafieifar5Ghasem Azizi Tabesh6Ghazaleh Rahimzadeh7Maryam Gholamalizadeh8Mark O. Goodarzi9Guilan University of Medical SciencesShahid Beheshti University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesOulu University Hospital and University of OuluShahid Beheshti University of Medical SciencesMinistry of HealthSchool of Medicine, Shahid Beheshti University of Medical SciencesDeakin UniversityShahid Beheshti University of Medical SciencesCedars-Sinai Medical CenterThis study is the first to identify the effects of FTO genotype on the interactions between the level of macro-nutrients intake and the expression level of fat mass and obesity associated (FTO) and homeobox transcription factor iriquois-3 (IRX3) genes This longitudinal study was carried out on 84 overweight and obese adolescent boys in Tehran, Iran. The rs9930506 SNP in FTO was genotyped at baseline and the level of FTO and IRX3 expression in PBMCs and macro-nutrients’ intake were assessed at baseline and after 18 weeks of the intervention. The results identified that the higher carbohydrates intake significantly up-regulated the FTO gene (P = 0.001) and down-regulated the IRX3 gene (P = 0.01). Protein intake up-regulated the FTO gene (P = 0.001). In carriers of GG genotype of FTO gene, the amount of dietary carbohydrate had a positive association with FTO gene expression (p = 0.001, and p = 0.04, respectively). In AA/AG carriers, dietary protein was positively associated with FTO gene expression (p = 0.001) and dietary carbohydrate was negatively associated with IRX3 gene expression (P = 0.04). Therefore, dietary carbohydrateseems to be associated with FTO and IRX3 genes expression. These associations are influenced by FTO genotype.http://dx.doi.org/10.1080/21623945.2019.1693745ftoirx3macronutrientsgenotypecarbohydrateproteinfat |
| spellingShingle | Saeid Doaei Naser Kalantari Pantea Izadi Tuire Salonurmi Alireza Mosavi Jarrahi Shahram Rafieifar Ghasem Azizi Tabesh Ghazaleh Rahimzadeh Maryam Gholamalizadeh Mark O. Goodarzi Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents Adipocyte fto irx3 macronutrients genotype carbohydrate protein fat |
| title | Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents |
| title_full | Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents |
| title_fullStr | Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents |
| title_full_unstemmed | Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents |
| title_short | Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents |
| title_sort | interactions between macro nutrients intake fto and irx3 gene expression and fto genotype in obese and overweight male adolescents |
| topic | fto irx3 macronutrients genotype carbohydrate protein fat |
| url | http://dx.doi.org/10.1080/21623945.2019.1693745 |
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