Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

Abstract Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero i...

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Bibliographic Details
Main Authors: Koen Van den Berge, Fanny Perraudeau, Charlotte Soneson, Michael I. Love, Davide Risso, Jean-Philippe Vert, Mark D. Robinson, Sandrine Dudoit, Lieven Clement
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Genome Biology
Subjects:
Single-cell RNA sequencing
Differential expression
Zero-inflated negative binomial
Weights
Online Access:http://link.springer.com/article/10.1186/s13059-018-1406-4

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