Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

Abstract The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM). Upon generation of stable phasic contractions, PDE‐4 and PDE‐5 inhibitors...

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Bibliographic Details
Main Authors: Iris Lim, Taishi Masutani, Hikaru Hashitani, Russ Chess‐Williams, Donna Sellers
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Pharmacology Research & Perspectives
Subjects:
phasic contractions
phosphodiesterase
phosphodiesterase inhibitors
roflumilast
rolipram
sildenafil
Online Access:https://doi.org/10.1002/prp2.1175

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