Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience
Psilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability...
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MDPI AG
2022-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/6/1004 |
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| author | Vojtěch Viktorin Inga Griškova-Bulanova Aleksandras Voicikas Dominika Dojčánová Peter Zach Anna Bravermanová Veronika Andrashko Filip Tylš Jakub Korčák Michaela Viktorinová Vlastimil Koudelka Kateřina Hájková Martin Kuchař Jiří Horáček Martin Brunovský Tomáš Páleníček |
| author_facet | Vojtěch Viktorin Inga Griškova-Bulanova Aleksandras Voicikas Dominika Dojčánová Peter Zach Anna Bravermanová Veronika Andrashko Filip Tylš Jakub Korčák Michaela Viktorinová Vlastimil Koudelka Kateřina Hájková Martin Kuchař Jiří Horáček Martin Brunovský Tomáš Páleníček |
| author_sort | Vojtěch Viktorin |
| collection | DOAJ |
| description | Psilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability to generate gamma activity. Based on previous literature, we studied the impact of psilocybin on 40 Hz ASSR in healthy volunteers. The study was double blind and placebo controlled with a crossover design. A sample of 20 healthy subjects (10M/10F) received psilocybin orally 0.26 mg/kg or placebo. Participants were measured four times in total, one time before ingestion of psilocybin/placebo and one time after ingestion, during the peak of intoxication. A series of 500 ms click trains were used for stimulation. Psilocybin induced a psychedelic effect and decreased 40 Hz ASSR phase-locking index compared to placebo. The extent of the attenuation was related to Cognition and Affect on the Hallucinogen Rating Scale. The current study shows that psilocybin lowers the synchronization level and the amplitude of 40 Hz auditory steady-state responses, which yields further support for the role of gamma oscillations in cognitive processing and its disturbance. |
| first_indexed | 2024-03-09T23:19:15Z |
| format | Article |
| id | doaj.art-1fbba6ff962243ecafb0fc06663a4854 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:19:15Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1fbba6ff962243ecafb0fc06663a48542023-11-23T17:29:07ZengMDPI AGJournal of Personalized Medicine2075-44262022-06-01126100410.3390/jpm12061004Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic ExperienceVojtěch Viktorin0Inga Griškova-Bulanova1Aleksandras Voicikas2Dominika Dojčánová3Peter Zach4Anna Bravermanová5Veronika Andrashko6Filip Tylš7Jakub Korčák8Michaela Viktorinová9Vlastimil Koudelka10Kateřina Hájková11Martin Kuchař12Jiří Horáček13Martin Brunovský14Tomáš Páleníček15National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicInstitute of Biosciences, Vilnius University, 7 Saulėtekio Ave, 10257 Vilnius, LithuaniaNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech RepublicForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicNational Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech RepublicPsilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability to generate gamma activity. Based on previous literature, we studied the impact of psilocybin on 40 Hz ASSR in healthy volunteers. The study was double blind and placebo controlled with a crossover design. A sample of 20 healthy subjects (10M/10F) received psilocybin orally 0.26 mg/kg or placebo. Participants were measured four times in total, one time before ingestion of psilocybin/placebo and one time after ingestion, during the peak of intoxication. A series of 500 ms click trains were used for stimulation. Psilocybin induced a psychedelic effect and decreased 40 Hz ASSR phase-locking index compared to placebo. The extent of the attenuation was related to Cognition and Affect on the Hallucinogen Rating Scale. The current study shows that psilocybin lowers the synchronization level and the amplitude of 40 Hz auditory steady-state responses, which yields further support for the role of gamma oscillations in cognitive processing and its disturbance.https://www.mdpi.com/2075-4426/12/6/1004psilocybinpsychedelicsauditory steady-state responsemodel of psychosisEEGserotonin |
| spellingShingle | Vojtěch Viktorin Inga Griškova-Bulanova Aleksandras Voicikas Dominika Dojčánová Peter Zach Anna Bravermanová Veronika Andrashko Filip Tylš Jakub Korčák Michaela Viktorinová Vlastimil Koudelka Kateřina Hájková Martin Kuchař Jiří Horáček Martin Brunovský Tomáš Páleníček Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience Journal of Personalized Medicine psilocybin psychedelics auditory steady-state response model of psychosis EEG serotonin |
| title | Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience |
| title_full | Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience |
| title_fullStr | Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience |
| title_full_unstemmed | Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience |
| title_short | Psilocybin—Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience |
| title_sort | psilocybin mediated attenuation of gamma band auditory steady state responses assr is driven by the intensity of cognitive and emotional domains of psychedelic experience |
| topic | psilocybin psychedelics auditory steady-state response model of psychosis EEG serotonin |
| url | https://www.mdpi.com/2075-4426/12/6/1004 |
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