Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies. Here, new therapeutic strategies designed to modulate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/17/4209 |
| _version_ | 1797496082217828352 |
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| author | Nebojsa Skorupan Mayrel Palestino Dominguez Samuel L. Ricci Christine Alewine |
| author_facet | Nebojsa Skorupan Mayrel Palestino Dominguez Samuel L. Ricci Christine Alewine |
| author_sort | Nebojsa Skorupan |
| collection | DOAJ |
| description | Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies. Here, new therapeutic strategies designed to modulate the cancer-associated fibroblast and immune compartments of pancreatic ductal adenocarcinomas are described and clinical trials of novel therapeutics are discussed. Continued advances in our understanding of the pancreatic cancer tumor microenvironment are generating stromal and immune-modulating therapeutics that may improve patient responses to anti-tumor treatment. |
| first_indexed | 2024-03-10T01:58:35Z |
| format | Article |
| id | doaj.art-1fbbfaf616b14bc993383750c4b42bbd |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:58:35Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1fbbfaf616b14bc993383750c4b42bbd2023-11-23T12:51:49ZengMDPI AGCancers2072-66942022-08-011417420910.3390/cancers14174209Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal AdenocarcinomaNebojsa Skorupan0Mayrel Palestino Dominguez1Samuel L. Ricci2Christine Alewine3Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USAPancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies. Here, new therapeutic strategies designed to modulate the cancer-associated fibroblast and immune compartments of pancreatic ductal adenocarcinomas are described and clinical trials of novel therapeutics are discussed. Continued advances in our understanding of the pancreatic cancer tumor microenvironment are generating stromal and immune-modulating therapeutics that may improve patient responses to anti-tumor treatment.https://www.mdpi.com/2072-6694/14/17/4209immunotherapypancreatic cancerstromal modifierscancer-associated fibroblasts |
| spellingShingle | Nebojsa Skorupan Mayrel Palestino Dominguez Samuel L. Ricci Christine Alewine Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma Cancers immunotherapy pancreatic cancer stromal modifiers cancer-associated fibroblasts |
| title | Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma |
| title_full | Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma |
| title_fullStr | Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma |
| title_full_unstemmed | Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma |
| title_short | Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma |
| title_sort | clinical strategies targeting the tumor microenvironment of pancreatic ductal adenocarcinoma |
| topic | immunotherapy pancreatic cancer stromal modifiers cancer-associated fibroblasts |
| url | https://www.mdpi.com/2072-6694/14/17/4209 |
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