Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
Abstract Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Pe...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-01-01
|
| Series: | npj Genomic Medicine |
| Online Access: | https://doi.org/10.1038/s41525-016-0004-1 |
| _version_ | 1819200206982348800 |
|---|---|
| author | Susan K. Delaney Ruth Brenner Tara J. Schmidlen Michael P. Dempsey Kim E. London Erynn S. Gordon Mark Bellafante Ashley Nasuti Laura B. Scheinfeldt Kaveri D. Rajula Leo Jose Joseph P. Jarvis Norman P. Gerry Michael F. Christman |
| author_facet | Susan K. Delaney Ruth Brenner Tara J. Schmidlen Michael P. Dempsey Kim E. London Erynn S. Gordon Mark Bellafante Ashley Nasuti Laura B. Scheinfeldt Kaveri D. Rajula Leo Jose Joseph P. Jarvis Norman P. Gerry Michael F. Christman |
| author_sort | Susan K. Delaney |
| collection | DOAJ |
| description | Abstract Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Personalized Medicine Collaborative expanded to create a military cohort, specifically, the United States Air Force. Initial recruitment focused on Air Force Medical Service personnel and later expanded to include all Active Duty Air Force members and beneficiaries. Now in its 6th year, the study has produced a wide variety of insights, including optimal study design for military-sponsored genomic research, and discussion on genetic information sharing between and amongst Air Force study participants, civilian and military researchers, and the United States Department of Defense. Over the longer term, analyses will further contribute to the development of policies and processes relevant to clinical decision support and data sharing within the US military, and on-going work with the Air Force Medical Service sub-cohort will generate critical insights into how best to deploy useful genomic information in clinical care. Here we discuss challenges faced and critical success factors for military-civilian collaborations around genomic research. |
| first_indexed | 2024-12-23T03:28:33Z |
| format | Article |
| id | doaj.art-1fbcf28497574158bb0e60cdda521aa4 |
| institution | Directory Open Access Journal |
| issn | 2056-7944 |
| language | English |
| last_indexed | 2024-12-23T03:28:33Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Genomic Medicine |
| spelling | doaj.art-1fbcf28497574158bb0e60cdda521aa42022-12-21T18:01:45ZengNature Portfolionpj Genomic Medicine2056-79442017-01-01211510.1038/s41525-016-0004-1Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air ForceSusan K. Delaney0Ruth Brenner1Tara J. Schmidlen2Michael P. Dempsey3Kim E. London4Erynn S. Gordon5Mark Bellafante6Ashley Nasuti7Laura B. Scheinfeldt8Kaveri D. Rajula9Leo Jose10Joseph P. Jarvis11Norman P. Gerry12Michael F. Christman13Coriell Institute for Medical ResearchAir Force Medical Support Agency, Defense Health HeadquartersCoriell Institute for Medical ResearchAir Force Medical Support Agency, Defense Health HeadquartersAir Force Research Laboratory, Institutional Review BoardCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchAbstract Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Personalized Medicine Collaborative expanded to create a military cohort, specifically, the United States Air Force. Initial recruitment focused on Air Force Medical Service personnel and later expanded to include all Active Duty Air Force members and beneficiaries. Now in its 6th year, the study has produced a wide variety of insights, including optimal study design for military-sponsored genomic research, and discussion on genetic information sharing between and amongst Air Force study participants, civilian and military researchers, and the United States Department of Defense. Over the longer term, analyses will further contribute to the development of policies and processes relevant to clinical decision support and data sharing within the US military, and on-going work with the Air Force Medical Service sub-cohort will generate critical insights into how best to deploy useful genomic information in clinical care. Here we discuss challenges faced and critical success factors for military-civilian collaborations around genomic research.https://doi.org/10.1038/s41525-016-0004-1 |
| spellingShingle | Susan K. Delaney Ruth Brenner Tara J. Schmidlen Michael P. Dempsey Kim E. London Erynn S. Gordon Mark Bellafante Ashley Nasuti Laura B. Scheinfeldt Kaveri D. Rajula Leo Jose Joseph P. Jarvis Norman P. Gerry Michael F. Christman Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force npj Genomic Medicine |
| title | Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force |
| title_full | Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force |
| title_fullStr | Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force |
| title_full_unstemmed | Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force |
| title_short | Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force |
| title_sort | precision military medicine conducting a multi site clinical utility study of genomic and lifestyle risk factors in the united states air force |
| url | https://doi.org/10.1038/s41525-016-0004-1 |
| work_keys_str_mv | AT susankdelaney precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT ruthbrenner precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT tarajschmidlen precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT michaelpdempsey precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT kimelondon precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT erynnsgordon precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT markbellafante precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT ashleynasuti precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT laurabscheinfeldt precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT kaveridrajula precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT leojose precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT josephpjarvis precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT normanpgerry precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce AT michaelfchristman precisionmilitarymedicineconductingamultisiteclinicalutilitystudyofgenomicandlifestyleriskfactorsintheunitedstatesairforce |