Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications
Additive manufacturing or 3D printing technologies might advance the fabrication sector of personalised biomaterials with high-tech precision. The selection of optimal precursor materials is considered the first key-step for the development of new printable filaments destined for the fabrication of...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/16/6/2359 |
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| author | Aura-Cătălina Mocanu Florin Miculescu Andreea Elena Constantinescu Mădălina-Andreea Pandele Ștefan Ioan Voicu Anișoara Cîmpean Marian Miculescu Andreea Mariana Negrescu |
| author_facet | Aura-Cătălina Mocanu Florin Miculescu Andreea Elena Constantinescu Mădălina-Andreea Pandele Ștefan Ioan Voicu Anișoara Cîmpean Marian Miculescu Andreea Mariana Negrescu |
| author_sort | Aura-Cătălina Mocanu |
| collection | DOAJ |
| description | Additive manufacturing or 3D printing technologies might advance the fabrication sector of personalised biomaterials with high-tech precision. The selection of optimal precursor materials is considered the first key-step for the development of new printable filaments destined for the fabrication of products with diverse orthopaedic/dental applications. The selection route of precursor materials proposed in this study targeted two categories of materials: prime materials, for the polymeric matrix (acrylonitrile butadiene styrene (ABS), polylactic acid (PLA)); and reinforcement materials (natural hydroxyapatite (HA) and graphene nanoplatelets (GNP) of different dimensions). HA was isolated from bovine bones (HA particles size < 40 μm, <100 μm, and >125 μm) through a reproducible synthesis technology. The structural (FTIR-ATR, Raman spectroscopy), morphological (SEM), and, most importantly, in vitro (indirect and direct contact studies) features of all precursor materials were comparatively evaluated. The polymeric materials were also prepared in the form of thin plates, for an advanced cell viability assessment (direct contact studies). The overall results confirmed once again the reproducibility of the HA synthesis method. Moreover, the biological cytotoxicity assays established the safe selection of PLA as a future polymeric matrix, with GNP of grade M as a reinforcement and HA as a bioceramic. Therefore, the obtained results pinpointed these materials as optimal for future composite filament synthesis and the 3D printing of implantable structures. |
| first_indexed | 2024-03-11T06:15:01Z |
| format | Article |
| id | doaj.art-1fbe6956751d4c5ea63154e3a08c337e |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-11T06:15:01Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-1fbe6956751d4c5ea63154e3a08c337e2023-11-17T12:21:09ZengMDPI AGMaterials1996-19442023-03-01166235910.3390/ma16062359Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical ApplicationsAura-Cătălina Mocanu0Florin Miculescu1Andreea Elena Constantinescu2Mădălina-Andreea Pandele3Ștefan Ioan Voicu4Anișoara Cîmpean5Marian Miculescu6Andreea Mariana Negrescu7Department of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, District 6, 060042 Bucharest, RomaniaDepartment of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, District 6, 060042 Bucharest, RomaniaDepartment of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, District 6, 060042 Bucharest, RomaniaDepartment of Analytical Chemistry and Environmental Engineering, University Politehnica of Bucharest, 1-7 Gh. Polizu Str., 011061 Bucharest, RomaniaDepartment of Analytical Chemistry and Environmental Engineering, University Politehnica of Bucharest, 1-7 Gh. Polizu Str., 011061 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, District 5, 050095 Bucharest, RomaniaDepartment of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, District 6, 060042 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, District 5, 050095 Bucharest, RomaniaAdditive manufacturing or 3D printing technologies might advance the fabrication sector of personalised biomaterials with high-tech precision. The selection of optimal precursor materials is considered the first key-step for the development of new printable filaments destined for the fabrication of products with diverse orthopaedic/dental applications. The selection route of precursor materials proposed in this study targeted two categories of materials: prime materials, for the polymeric matrix (acrylonitrile butadiene styrene (ABS), polylactic acid (PLA)); and reinforcement materials (natural hydroxyapatite (HA) and graphene nanoplatelets (GNP) of different dimensions). HA was isolated from bovine bones (HA particles size < 40 μm, <100 μm, and >125 μm) through a reproducible synthesis technology. The structural (FTIR-ATR, Raman spectroscopy), morphological (SEM), and, most importantly, in vitro (indirect and direct contact studies) features of all precursor materials were comparatively evaluated. The polymeric materials were also prepared in the form of thin plates, for an advanced cell viability assessment (direct contact studies). The overall results confirmed once again the reproducibility of the HA synthesis method. Moreover, the biological cytotoxicity assays established the safe selection of PLA as a future polymeric matrix, with GNP of grade M as a reinforcement and HA as a bioceramic. Therefore, the obtained results pinpointed these materials as optimal for future composite filament synthesis and the 3D printing of implantable structures.https://www.mdpi.com/1996-1944/16/6/2359materials selection3D printingABSPLAGNPnatural HA |
| spellingShingle | Aura-Cătălina Mocanu Florin Miculescu Andreea Elena Constantinescu Mădălina-Andreea Pandele Ștefan Ioan Voicu Anișoara Cîmpean Marian Miculescu Andreea Mariana Negrescu Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications Materials materials selection 3D printing ABS PLA GNP natural HA |
| title | Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications |
| title_full | Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications |
| title_fullStr | Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications |
| title_full_unstemmed | Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications |
| title_short | Selection Route of Precursor Materials in 3D Printing Composite Filament Development for Biomedical Applications |
| title_sort | selection route of precursor materials in 3d printing composite filament development for biomedical applications |
| topic | materials selection 3D printing ABS PLA GNP natural HA |
| url | https://www.mdpi.com/1996-1944/16/6/2359 |
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