Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice

A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In humans, pancreata from T1D deceased donors exhibit s...

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Bibliographic Details
Main Authors: Yesica Garciafigueroa, Brett E. Phillips, Carl Engman, Massimo Trucco, Nick Giannoukakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
neutrophils
type 1 diabetes
autoimmunity
neutrophil elastase
myeloperoxidase
non-obese diabetes (NOD) mice
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.565981/full

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