Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment
Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/2310-2861/9/4/286 |
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| author | Shuaiqi Gan Yongzhi Wu Xu Zhang Zheng Zheng Min Zhang Li Long Jinfeng Liao Wenchuan Chen |
| author_facet | Shuaiqi Gan Yongzhi Wu Xu Zhang Zheng Zheng Min Zhang Li Long Jinfeng Liao Wenchuan Chen |
| author_sort | Shuaiqi Gan |
| collection | DOAJ |
| description | Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic therapy, which causes localized chemical damage by generated reactive oxygen species (ROS). Conventional phototherapies suffer a major shortcoming in their clinical application due to their phototoxicity, which primarily arises from the uncontrolled distribution of phototherapeutic agents in vivo. For successful antitumor phototherapy, it is essential to ensure the generation of heat or ROS specifically occurs at the tumor site. To minimize the reverse side effects of phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based phototherapy for tumor treatment. The utilization of hydrogels as drug carriers allows for the sustained delivery of phototherapeutic agents to tumor sites, thereby limiting their adverse effects. Herein, we summarize the recent advancements in the design of hydrogels for antitumor phototherapy, offer a comprehensive overview of the latest advances in hydrogel-based phototherapy and its combination with other therapeutic modalities for tumor treatment, and discuss the current clinical status of hydrogel-based antitumor phototherapy. |
| first_indexed | 2024-03-11T04:59:47Z |
| format | Article |
| id | doaj.art-1fbecab4b3624ee5b51faac98c1740a5 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T04:59:47Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-1fbecab4b3624ee5b51faac98c1740a52023-11-17T19:21:18ZengMDPI AGGels2310-28612023-04-019428610.3390/gels9040286Recent Advances in Hydrogel-Based Phototherapy for Tumor TreatmentShuaiqi Gan0Yongzhi Wu1Xu Zhang2Zheng Zheng3Min Zhang4Li Long5Jinfeng Liao6Wenchuan Chen7State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaPhototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic therapy, which causes localized chemical damage by generated reactive oxygen species (ROS). Conventional phototherapies suffer a major shortcoming in their clinical application due to their phototoxicity, which primarily arises from the uncontrolled distribution of phototherapeutic agents in vivo. For successful antitumor phototherapy, it is essential to ensure the generation of heat or ROS specifically occurs at the tumor site. To minimize the reverse side effects of phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based phototherapy for tumor treatment. The utilization of hydrogels as drug carriers allows for the sustained delivery of phototherapeutic agents to tumor sites, thereby limiting their adverse effects. Herein, we summarize the recent advancements in the design of hydrogels for antitumor phototherapy, offer a comprehensive overview of the latest advances in hydrogel-based phototherapy and its combination with other therapeutic modalities for tumor treatment, and discuss the current clinical status of hydrogel-based antitumor phototherapy.https://www.mdpi.com/2310-2861/9/4/286hydrogelphotodynamic therapyphotothermal therapyantitumor |
| spellingShingle | Shuaiqi Gan Yongzhi Wu Xu Zhang Zheng Zheng Min Zhang Li Long Jinfeng Liao Wenchuan Chen Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment Gels hydrogel photodynamic therapy photothermal therapy antitumor |
| title | Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment |
| title_full | Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment |
| title_fullStr | Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment |
| title_full_unstemmed | Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment |
| title_short | Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment |
| title_sort | recent advances in hydrogel based phototherapy for tumor treatment |
| topic | hydrogel photodynamic therapy photothermal therapy antitumor |
| url | https://www.mdpi.com/2310-2861/9/4/286 |
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