Children, comorbidities and COVID-19 - What tilts the balance?
Background: Data on the outcome of children with SARS-COV-2 infection (COVID-19) is still evolving as the pandemic unfolds. Aims and Objective: The present study aims at describing the clinical severity, course and outcome of COVID-19 in children who had underlying illnesses or co-infections....
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2021-03-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/32738 |
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| author | Umesh Shukla Nita Radhakrishnan Bhanu Kiran Bhakhri Ravi Shankar Sohini Ghosh Vikas Jain Dharmendra K Singh Devendra K Gupta |
| author_facet | Umesh Shukla Nita Radhakrishnan Bhanu Kiran Bhakhri Ravi Shankar Sohini Ghosh Vikas Jain Dharmendra K Singh Devendra K Gupta |
| author_sort | Umesh Shukla |
| collection | DOAJ |
| description | Background: Data on the outcome of children with SARS-COV-2 infection (COVID-19) is still evolving as the pandemic unfolds.
Aims and Objective: The present study aims at describing the clinical severity, course and outcome of COVID-19 in children who had underlying illnesses or co-infections.
Materials and Methods: Retrospective, single center, observational study, conducted in a pediatric tertiary care center at Noida (National Capital Region, India).
Results: We analyzed the data of 15 children with co-morbidities associated with COVID-19. Cancer (n=4, 26.6%), co-infections (n=5, 33.3%), Thalassemia major (n=2, 13.3%) and one child each with celiac disease, cholelithiasis, Duchenne muscular dystrophy and multiple rib fractures were diagnosed with COVID-19. None were asymptomatic. 9 children (60%) had mild symptoms and 4 had moderate symptoms (26.6%) with respiratory distress. 2 children had severe respiratory distress requiring high flow oxygen. Convalescent plasma, IVIG, Oseltamivir, Azithromycin, Hydroxychloroquine were given as treatment in varying combinations. All children recovered from COVID-19.
Conclusion: Active malignancy, hypogammaglobinemia, underlying lung disease were associated with moderate to severe symptoms in this series of patients. Convalescent plasma helped in both children with severe hypoxia. |
| first_indexed | 2024-12-14T10:22:01Z |
| format | Article |
| id | doaj.art-1fc05bb35d864aacb573409cd875a0b8 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-14T10:22:01Z |
| publishDate | 2021-03-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-1fc05bb35d864aacb573409cd875a0b82022-12-21T23:06:32ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762021-03-011231013https://doi.org/10.3126/ajms.v12i3.32738Children, comorbidities and COVID-19 - What tilts the balance?Umesh Shukla0Nita Radhakrishnan 1https://orcid.org/0000-0002-7941-5641Bhanu Kiran Bhakhri2Ravi Shankar 3Sohini Ghosh 4Vikas Jain 5Dharmendra K Singh 6Devendra K Gupta 7Assistant Professor, Department of Pediatric Gastroenterology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaAssistant Professor, Department of Pediatric Hematology-Oncology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India Associate Professor, Department of Pediatric Medicine, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaIAP Fellow, Department of Pediatric Hematology-Oncology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaSenior Resident, Department of Pediatric Medicine, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaAssistant Professor, Department of Pediatric Gastroenterology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaProfessor, Department of Pediatric Medicine, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaDirector, SSPHPGTI and Professor, Department of Pediatric Surgery, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, IndiaBackground: Data on the outcome of children with SARS-COV-2 infection (COVID-19) is still evolving as the pandemic unfolds. Aims and Objective: The present study aims at describing the clinical severity, course and outcome of COVID-19 in children who had underlying illnesses or co-infections. Materials and Methods: Retrospective, single center, observational study, conducted in a pediatric tertiary care center at Noida (National Capital Region, India). Results: We analyzed the data of 15 children with co-morbidities associated with COVID-19. Cancer (n=4, 26.6%), co-infections (n=5, 33.3%), Thalassemia major (n=2, 13.3%) and one child each with celiac disease, cholelithiasis, Duchenne muscular dystrophy and multiple rib fractures were diagnosed with COVID-19. None were asymptomatic. 9 children (60%) had mild symptoms and 4 had moderate symptoms (26.6%) with respiratory distress. 2 children had severe respiratory distress requiring high flow oxygen. Convalescent plasma, IVIG, Oseltamivir, Azithromycin, Hydroxychloroquine were given as treatment in varying combinations. All children recovered from COVID-19. Conclusion: Active malignancy, hypogammaglobinemia, underlying lung disease were associated with moderate to severe symptoms in this series of patients. Convalescent plasma helped in both children with severe hypoxia.https://www.nepjol.info/index.php/AJMS/article/view/32738covid-19comorbiditieschildrencancer |
| spellingShingle | Umesh Shukla Nita Radhakrishnan Bhanu Kiran Bhakhri Ravi Shankar Sohini Ghosh Vikas Jain Dharmendra K Singh Devendra K Gupta Children, comorbidities and COVID-19 - What tilts the balance? Asian Journal of Medical Sciences covid-19 comorbidities children cancer |
| title | Children, comorbidities and COVID-19 - What tilts the balance? |
| title_full | Children, comorbidities and COVID-19 - What tilts the balance? |
| title_fullStr | Children, comorbidities and COVID-19 - What tilts the balance? |
| title_full_unstemmed | Children, comorbidities and COVID-19 - What tilts the balance? |
| title_short | Children, comorbidities and COVID-19 - What tilts the balance? |
| title_sort | children comorbidities and covid 19 what tilts the balance |
| topic | covid-19 comorbidities children cancer |
| url | https://www.nepjol.info/index.php/AJMS/article/view/32738 |
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