Optimizing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation: Insights from the ORCA Trial—A Retrospective Study on 10 Years of Practice

Optimizing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation: Insights from the ORCA Trial—A Retrospective Study on 10 Years of Practice

(1) Background: Citrate is preferred in continuous renal replacement therapy (CRRT) for critically ill patients because it prolongs filter life and reduces bleeding risks compared to unfractionated heparin (UFH). However, regional citrate anticoagulation (RCA) can lead to acid–base disturbances, cit...

Descripció completa

Dades bibliogràfiques
Autors principals:	Rita Jacobs, Walter Verbrugghe, Jason Bouziotis, Ingrid Baar, Karolien Dams, Annick De Weerdt, Philippe G. Jorens
Format:	Article
Idioma:	English
Publicat:	MDPI AG 2024-10-01
Col·lecció:	Life
Matèries:	citrate anticoagulation heparin renal replacement therapy filter lifespan bleeding acid–base disturbances
Accés en línia:	https://www.mdpi.com/2075-1729/14/10/1304

Ítems similars

Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy: Is Metabolic Fear the Enemy of Logic? A Systematic Review and Meta-Analysis of Randomised Controlled Trials
per: Rita Jacobs, et al.
Publicat: (2023-05-01)

Adverse events with regional citrate anticoagulation versus heparin anticoagulation during continuous renal replacement therapy: a systematic review and trial sequential analysis
per: Min-min Wang, et al.
Publicat: (2023-10-01)

Citrate and low-dose heparin combined anticoagulation in pediatric continuous renal replacement therapy
per: Desheng Zhu, et al.
Publicat: (2024-06-01)

Heparin anticoagulation versus regional citrate anticoagulation for membrane therapeutic plasma exchange in patients with increased bleeding risk
per: Jing Jiao, et al.
Publicat: (2023-12-01)

Anticoagulation strategies for pediatric continuous renal replacement therapy
per: Aakash Chandran Chidambaram, et al.
Publicat: (2024-09-01)

Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
per: Willem Boer, et al.
Publicat: (2023-03-01)

Comparison between regional citrate anticoagulation and heparin for intermittent hemodialysis in ICU patients: a propensity score-matched cohort study
per: Christophe Leroy, et al.
Publicat: (2021-01-01)

Flexitrate regional citrate anticoagulation in continuous venovenous hemodiafiltration: a retrospective analysis
per: Ilan Lenga, et al.
Publicat: (2019-12-01)

Regional citrate anticoagulation for continuous renal replacement therapy in newborns
per: Haixia Huang, et al.
Publicat: (2023-03-01)

Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study
per: Dan Liu, et al.
Publicat: (2024-01-01)

Comparison of Citrate and Heparin for Continuous Renal Replacement Therapy in Pediatric Intensive Units
per: Edin Botan, et al.
Publicat: (2023-12-01)

Analysis of Leukocyte Recruitment in Continuous Veno-Venous Hemofiltration with Regional Citrate vs. Systemic Heparin Anticoagulation
per: Andreas Margraf, et al.
Publicat: (2022-06-01)

Novel blood product transfusion regimen to prevent clotting and citrate accumulation during continuous renal replacement therapy with regional citrate anticoagulation in children
per: Yuelin Sun, et al.
Publicat: (2023-06-01)

Simple citrate anticoagulation protocol for low flux haemodialysis
per: Eng Kuang Lim, et al.
Publicat: (2018-01-01)

Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: a systematic review and meta-analysis
per: Wei Zhang, et al.
Publicat: (2019-01-01)

Construction and validation of a prediction model for the risk of citrate accumulation in patients with hepatic insufficiency receiving continuous renal replacement therapy with citrate anticoagulation
per: Quxia Hong, et al.
Publicat: (2024-01-01)

Complications of regional citrate anticoagulation: accumulation or overload?
per: Antoine G. Schneider, et al.
Publicat: (2017-11-01)

Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus
per: Shu-Yuan Liu, et al.
Publicat: (2023-05-01)

Clinical application of regional citrate anticoagulation for continuous renal replacement therapy in children with liver injury
per: Fang Hu, et al.
Publicat: (2022-10-01)

Regional citrate anticoagulation (RCA) in critically ill patients undergoing renal replacement therapy (RRT): expert opinion from the SIAARTI-SIN joint commission
per: Valentina Pistolesi, et al.
Publicat: (2023-03-01)

Regional citrate anticoagulation for replacement therapy in patients with liver failure: A systematic review and meta-analysis
per: Bo Peng, et al.
Publicat: (2023-02-01)

Efficacy and safety of low-molecular-weight-heparin plus citrate in nephrotic syndrome during continuous kidney replacement therapy: retrospective study
per: Di Wang, et al.
Publicat: (2025-02-01)

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction
per: Matthias Klingele, et al.
Publicat: (2017-11-01)

A safe and effective protocol for postdilution hemofiltration with regional citrate anticoagulation
per: Thomas Dimski, et al.
Publicat: (2024-07-01)

The effect of regional citrate anti-coagulation on the coagulation system in critically ill patients receiving continuous renal replacement therapy for acute kidney injury - an observational cohort study
per: Richard Fisher, et al.
Publicat: (2017-10-01)

Use of regional citrate anticoagulation with medium cut-off membrane: pilot report
per: Marija Malgaj Vrečko, et al.
Publicat: (2022-10-01)

Magnitude of hemorrhagic complications and its associated factors among patients on anticoagulant therapy at University of Gondar Comprehensive and Specialized Hospital, Northwest Ethiopia
per: Eden Abetu Mehari, et al.
Publicat: (2023-03-01)

Applying Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy for Acute Kidney Injury Patients with Acute Liver Dysfunction: a Retrospective Observational Study
per: Ying Yu, et al.
Publicat: (2018-07-01)

Determinants of Calcium Infusion Rate During Continuous Veno-venous Hemofiltration with Regional Citrate Anticoagulation in Critically Ill Patients with Acute Kidney Injury
per: De-Lin Liu, et al.
Publicat: (2016-01-01)

Deciphering simplified regional anticoagulation with citrate in intermittent hemodialysis: a clinical and computational study
per: Julien Aniort, et al.
Publicat: (2024-08-01)

Regional citrate anticoagulation versus low molecular weight heparin anticoagulation for continuous venovenous hemofiltration in patients with severe hypercalcemia: a retrospective cohort study
per: Yan Yu, et al.
Publicat: (2020-01-01)

Safety and Metabolic Tolerance of Citrate Anticoagulation in Critically Ill Polytrauma Patients with Acute Kidney Injury Requiring an Early Continuous Kidney Replacement Therapy
per: Filippo Mariano, et al.
Publicat: (2023-09-01)

Clinical application of regional citrate anticoagulation for membrane-based therapeutic plasma exchange in children with liver failure
per: Jun Hu, et al.
Publicat: (2023-10-01)

Effect of Anticoagulant Administration on the Mortality of Hospitalized Patients With COVID-19: An Updated Systematic Review and Meta-Analysis
per: Luojia Jiang, et al.
Publicat: (2021-08-01)

Automated regional citrate anticoagulation system based on individualized dosing models in nonliver failure patients undergoing PIRRT therapy
per: Qi Zhang, et al.
Publicat: (2024-12-01)

Study on the application of a segmented sodium citrate solution anticoagulation strategy in critically ill patients receiving CRRT: a prospective, randomized controlled study
per: Yu Chen, et al.
Publicat: (2024-08-01)

Updates in Anticoagulation Therapy Monitoring
per: Hannah L. McRae, et al.
Publicat: (2021-03-01)

Variations in the full blood count parameters among apparently healthy humans in the Ho municipality using ethylenediamine tetraacetic acid (EDTA), sodium citrate and lithium heparin anticoagulants: A laboratory-based cross-sectional analytical study
per: Elliot Elikplim Akorsu, et al.
Publicat: (2023-06-01)

Evaluation of EDTA induced pseudothrombocytopenia and the effect of alternative anticoagulants
per: A Shrestha, et al.
Publicat: (2014-09-01)

The effects of differing anticoagulant regimes on blood quality after cell salvage in coronary artery bypass grafting (CABG): a pilot study
per: Willem Boer, et al.
Publicat: (2023-04-01)