Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice
Camellia oil is a traditional Chinese medicine and a nutritional food, it is one of the best health foods for the prevention of Alzheimer's disease (AD). The aim of this study was to investigate the therapeutic effects of camellia oil in AD in terms of intestinal microbiota and lipid metabolism...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002845 |
| _version_ | 1811338179744104448 |
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| author | Pengli Guo Mengnan Zeng Bing Cao Meng Liu Yuhan Zhang Jufang Jia Qinqin Zhang Beibei Zhang Ru Wang Weizheng Xiong Xiaoke Zheng Weisheng Feng |
| author_facet | Pengli Guo Mengnan Zeng Bing Cao Meng Liu Yuhan Zhang Jufang Jia Qinqin Zhang Beibei Zhang Ru Wang Weizheng Xiong Xiaoke Zheng Weisheng Feng |
| author_sort | Pengli Guo |
| collection | DOAJ |
| description | Camellia oil is a traditional Chinese medicine and a nutritional food, it is one of the best health foods for the prevention of Alzheimer's disease (AD). The aim of this study was to investigate the therapeutic effects of camellia oil in AD in terms of intestinal microbiota and lipid metabolism. To assess changes in mouse behavior, brain pathology, gut microbiota, PPARs receptors and lipid metabolism related proteins in brain tissue, immune cells, and levels of inflammation in the brain. The integrated results show camellia oil may improve memory impairment in mice by mediating in vivo immune cells and inflammation in the brain through PPARs, which further affect gut microbiota and lipid metabolism. These data provide pharmacological rationale for camellia oil in the treatment of AD and support its value as a nutritional food. |
| first_indexed | 2024-04-13T18:06:12Z |
| format | Article |
| id | doaj.art-1fc25ca3d5c6465c9ac84e18f27a3a93 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T18:06:12Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1fc25ca3d5c6465c9ac84e18f27a3a932022-12-22T02:36:03ZengElsevierJournal of Functional Foods1756-46462022-09-0196105214Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in micePengli Guo0Mengnan Zeng1Bing Cao2Meng Liu3Yuhan Zhang4Jufang Jia5Qinqin Zhang6Beibei Zhang7Ru Wang8Weizheng Xiong9Xiaoke Zheng10Weisheng Feng11Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, ChinaHenan Luda Camellia Oil Co., Ltd., 59 Jiefang Road, Xinyang 465550, ChinaHenan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, China; Corresponding authors at: Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China.Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, 156 Jinshui East Road, Zhengzhou 450046, China; Corresponding authors at: Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China.Camellia oil is a traditional Chinese medicine and a nutritional food, it is one of the best health foods for the prevention of Alzheimer's disease (AD). The aim of this study was to investigate the therapeutic effects of camellia oil in AD in terms of intestinal microbiota and lipid metabolism. To assess changes in mouse behavior, brain pathology, gut microbiota, PPARs receptors and lipid metabolism related proteins in brain tissue, immune cells, and levels of inflammation in the brain. The integrated results show camellia oil may improve memory impairment in mice by mediating in vivo immune cells and inflammation in the brain through PPARs, which further affect gut microbiota and lipid metabolism. These data provide pharmacological rationale for camellia oil in the treatment of AD and support its value as a nutritional food.http://www.sciencedirect.com/science/article/pii/S1756464622002845Alzheimer's diseaseCamellia oilGut microbiotaLipid metabolismPPARs |
| spellingShingle | Pengli Guo Mengnan Zeng Bing Cao Meng Liu Yuhan Zhang Jufang Jia Qinqin Zhang Beibei Zhang Ru Wang Weizheng Xiong Xiaoke Zheng Weisheng Feng Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice Journal of Functional Foods Alzheimer's disease Camellia oil Gut microbiota Lipid metabolism PPARs |
| title | Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice |
| title_full | Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice |
| title_fullStr | Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice |
| title_full_unstemmed | Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice |
| title_short | Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice |
| title_sort | camellia oil improves aβ25 35 induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice |
| topic | Alzheimer's disease Camellia oil Gut microbiota Lipid metabolism PPARs |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002845 |
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