Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

Loss of pancreatic β-cell function is a critical event in the pathophysiology of type 2 diabetes. However, studies of its underlying mechanisms as well as the discovery of novel targets and therapies have been hindered due to limitations in available experimental models. In this study we exploited t...

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Bibliographic Details
Main Authors: Joan Mir-Coll, Tilo Moede, Meike Paschen, Aparna Neelakandhan, Ismael Valladolid-Acebes, Barbara Leibiger, Adelinn Biernath, Carina Ämmälä, Ingo B. Leibiger, Burcak Yesildag, Per-Olof Berggren
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes
β-cell dysfunction
glucotoxicity
glucolipotoxicity
pancreatic islets
viral transduction
Online Access:https://www.mdpi.com/1422-0067/22/4/1813

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