Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorde...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms16041 |
| _version_ | 1818993940844511232 |
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| author | Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley |
| author_facet | Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley |
| author_sort | Konrad Buscher |
| collection | DOAJ |
| description | The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans. |
| first_indexed | 2024-12-20T20:50:03Z |
| format | Article |
| id | doaj.art-1fc27041918b48b8a2944c3034860cf1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:50:03Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1fc27041918b48b8a2944c3034860cf12022-12-21T19:26:57ZengNature PortfolioNature Communications2041-17232017-07-018111010.1038/ncomms16041Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survivalKonrad Buscher0Erik Ehinger1Pritha Gupta2Akula Bala Pramod3Dennis Wolf4George Tweet5Calvin Pan6Charles D. Mills7Aldons J. Lusis8Klaus Ley9Division of Inflammation Biology, La Jolla Institute for Allergy and ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy and ImmunologyDepartments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of CaliforniaDivision of Inflammation Biology, La Jolla Institute for Allergy and ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy and ImmunologyDivision of Inflammation Biology, La Jolla Institute for Allergy and ImmunologyDepartments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of CaliforniaBioMedical ConsultantsDepartments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of CaliforniaDivision of Inflammation Biology, La Jolla Institute for Allergy and ImmunologyThe inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.https://doi.org/10.1038/ncomms16041 |
| spellingShingle | Konrad Buscher Erik Ehinger Pritha Gupta Akula Bala Pramod Dennis Wolf George Tweet Calvin Pan Charles D. Mills Aldons J. Lusis Klaus Ley Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival Nature Communications |
| title | Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
| title_full | Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
| title_fullStr | Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
| title_full_unstemmed | Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
| title_short | Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival |
| title_sort | natural variation of macrophage activation as disease relevant phenotype predictive of inflammation and cancer survival |
| url | https://doi.org/10.1038/ncomms16041 |
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