The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats
Objective(s): Cholecystokinin (CCK) has been proposed as a mediator in stress. However, it is still not fully documented what are its effects. We aimed to evaluate the effects of systemic administration of CCK exactly before induction of stress on spatial memory and synaptic plasticity at CA1 in rat...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-12-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_9619_993cf8a034ea646c3fbb43cf112e9092.pdf |
| _version_ | 1811287863753441280 |
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| author | Malihe Sadeghi Parham Reisi Maryam Radahmadi |
| author_facet | Malihe Sadeghi Parham Reisi Maryam Radahmadi |
| author_sort | Malihe Sadeghi |
| collection | DOAJ |
| description | Objective(s): Cholecystokinin (CCK) has been proposed as a mediator in stress. However, it is still not fully documented what are its effects. We aimed to evaluate the effects of systemic administration of CCK exactly before induction of stress on spatial memory and synaptic plasticity at CA1 in rats. Materials and Methods: Male Wistar rats were divided into 4 groups: the control, the control-CCK, the stress and the stress-CCK. Restraint stress was induced 6 hr per day, for 24 days. Cholecystokinin sulfated octapeptide (CCK-8S) was injected (1.6 µg/kg, IP) before each session of stress induction. Spatial memory was evaluated by Morris water maze test. Long term potentiation (LTP) in Schaffer collateral-CA1 synapses was assessed (by 100 Hz tetanization) in order to investigate synaptic plasticity. Results: Stress impaired spatial memory significantly (P |
| first_indexed | 2024-04-13T03:25:53Z |
| format | Article |
| id | doaj.art-1fc3f99ccaf34fffa3640fe0ce5a9a80 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T03:25:53Z |
| publishDate | 2017-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-1fc3f99ccaf34fffa3640fe0ce5a9a802022-12-22T03:04:38ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742017-12-0120121368137610.22038/ijbms.2017.96199619The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in ratsMalihe Sadeghi0Parham Reisi1Maryam Radahmadi2Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranObjective(s): Cholecystokinin (CCK) has been proposed as a mediator in stress. However, it is still not fully documented what are its effects. We aimed to evaluate the effects of systemic administration of CCK exactly before induction of stress on spatial memory and synaptic plasticity at CA1 in rats. Materials and Methods: Male Wistar rats were divided into 4 groups: the control, the control-CCK, the stress and the stress-CCK. Restraint stress was induced 6 hr per day, for 24 days. Cholecystokinin sulfated octapeptide (CCK-8S) was injected (1.6 µg/kg, IP) before each session of stress induction. Spatial memory was evaluated by Morris water maze test. Long term potentiation (LTP) in Schaffer collateral-CA1 synapses was assessed (by 100 Hz tetanization) in order to investigate synaptic plasticity. Results: Stress impaired spatial memory significantly (Phttp://ijbms.mums.ac.ir/article_9619_993cf8a034ea646c3fbb43cf112e9092.pdfCA1Cholecystokinin sulfated octapeptideHippocampusLong term potentiationMemorystress |
| spellingShingle | Malihe Sadeghi Parham Reisi Maryam Radahmadi The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats Iranian Journal of Basic Medical Sciences CA1 Cholecystokinin sulfated octapeptide Hippocampus Long term potentiation Memory stress |
| title | The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats |
| title_full | The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats |
| title_fullStr | The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats |
| title_full_unstemmed | The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats |
| title_short | The effects of CCK-8S on spatial memory and long-term potentiation at CA1 during induction of stress in rats |
| title_sort | effects of cck 8s on spatial memory and long term potentiation at ca1 during induction of stress in rats |
| topic | CA1 Cholecystokinin sulfated octapeptide Hippocampus Long term potentiation Memory stress |
| url | http://ijbms.mums.ac.ir/article_9619_993cf8a034ea646c3fbb43cf112e9092.pdf |
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