Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis

Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis

Lactate and tumor cell-derived extracellular vesicles (TEVs) both contribute to tumor progression. However, it is still unclear whether lactate can accelerate tumor development by directly promoting TEV production. Here, we show that lactate decreases intracellular cAMP levels and subsequent PKA act...

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Bibliographic Details
Main Authors: Man Luo, Junqi Zhu, Jie Ren, Yuxiao Tong, Limin Wang, Shenglin Ma, Jiaoli Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
lactate
extracellular vesicles
tumor
GPR81
HIF-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1036543/full

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