Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children
Abstract Background We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure on children’s eating behavior, which is often altered in those with deve...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-018-1171-2 |
| _version_ | 1818009577897066496 |
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| author | Anh Thi Nguyet Nguyen Muneko Nishijo Tai The Pham Nghi Ngoc Tran Anh Hai Tran Luong Van Hoang Hitomi Boda Yuko Morikawa Yoshikazu Nishino Hisao Nishijo |
| author_facet | Anh Thi Nguyet Nguyen Muneko Nishijo Tai The Pham Nghi Ngoc Tran Anh Hai Tran Luong Van Hoang Hitomi Boda Yuko Morikawa Yoshikazu Nishino Hisao Nishijo |
| author_sort | Anh Thi Nguyet Nguyen |
| collection | DOAJ |
| description | Abstract Background We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure on children’s eating behavior, which is often altered in those with developmental disorders. Methods A total of 185 mother-and-child pairs previously enrolled in a birth cohort in dioxin-contaminated areas participated in this survey, conducted when the children reached 3 years of age. Perinatal dioxin exposure levels in the children were estimated using dioxin levels in maternal breast milk after birth. Mothers were interviewed using the Children’s Eating Behaviour Questionnaire (CEBQ). A multiple linear regression model was used to analyze the association between dioxin exposure and CEBQ scores, after controlling for covariates such as location, parity, maternal age, maternal education, maternal body mass index, family income, children’s gestational age at delivery, and children’s age at the time of the survey. A general linear model was used to analyze the effects of sex and dioxin exposure on CEBQ scores. Results There was no significant association between most dioxin congeners or toxic equivalencies of polychlorinated dibenzo-p-dioxins/furans (TEQ-PCDDs/Fs) and CEBQ scores in boys, although significant associations between some eating behavior sub-scores and 1,2,3,4,6,7,8,9-octachlorodibenzofuran were observed. In girls, there was a significant inverse association between levels of TEQ-PCDFs and enjoyment of food scores and between levels of TEQ-PCDFs and TEQ-PCDDs/Fs and desire to drink scores. Two pentachlorodibenzofuran congeners and 1,2,3,6,7,8-hexachlorodibenzofuran were associated with a decreased enjoyment of food score, and seven PCDF congeners were associated with a decreased desire to drink score. The adjusted mean enjoyment of food score was significantly lower in children of both sexes exposed to high levels of TEQ-PCDFs. There was, however, a significant interaction between sex and TEQ-PCDF exposure in their effect on desire to drink scores, especially in girls. Conclusions Perinatal exposure to dioxin can influence eating behavior in children and particularly in girls. A longer follow-up study would be required to assess whether emotional development that affects eating styles and behaviors is related to dioxin exposure. |
| first_indexed | 2024-04-14T05:44:37Z |
| format | Article |
| id | doaj.art-1fc572caebc84c61aa9bf98ee5047955 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-04-14T05:44:37Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj.art-1fc572caebc84c61aa9bf98ee50479552022-12-22T02:09:20ZengBMCBMC Pediatrics1471-24312018-07-011811910.1186/s12887-018-1171-2Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese childrenAnh Thi Nguyet Nguyen0Muneko Nishijo1Tai The Pham2Nghi Ngoc Tran3Anh Hai Tran4Luong Van Hoang5Hitomi Boda6Yuko Morikawa7Yoshikazu Nishino8Hisao Nishijo9Department of Public Health and Epidemiology, Kanazawa Medical UniversityDepartment of Public Health and Epidemiology, Kanazawa Medical UniversityBiomedical and Pharmaceutical Research Center, Vietnam Military Medical UniversityDepartment of Public Health and Epidemiology, Kanazawa Medical UniversityBiomedical and Pharmaceutical Research Center, Vietnam Military Medical UniversityBiomedical and Pharmaceutical Research Center, Vietnam Military Medical UniversitySchool of Nursing, Kanazawa Medical UniversitySchool of Nursing, Kanazawa Medical UniversityDepartment of Public Health and Epidemiology, Kanazawa Medical UniversitySystem Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaAbstract Background We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure on children’s eating behavior, which is often altered in those with developmental disorders. Methods A total of 185 mother-and-child pairs previously enrolled in a birth cohort in dioxin-contaminated areas participated in this survey, conducted when the children reached 3 years of age. Perinatal dioxin exposure levels in the children were estimated using dioxin levels in maternal breast milk after birth. Mothers were interviewed using the Children’s Eating Behaviour Questionnaire (CEBQ). A multiple linear regression model was used to analyze the association between dioxin exposure and CEBQ scores, after controlling for covariates such as location, parity, maternal age, maternal education, maternal body mass index, family income, children’s gestational age at delivery, and children’s age at the time of the survey. A general linear model was used to analyze the effects of sex and dioxin exposure on CEBQ scores. Results There was no significant association between most dioxin congeners or toxic equivalencies of polychlorinated dibenzo-p-dioxins/furans (TEQ-PCDDs/Fs) and CEBQ scores in boys, although significant associations between some eating behavior sub-scores and 1,2,3,4,6,7,8,9-octachlorodibenzofuran were observed. In girls, there was a significant inverse association between levels of TEQ-PCDFs and enjoyment of food scores and between levels of TEQ-PCDFs and TEQ-PCDDs/Fs and desire to drink scores. Two pentachlorodibenzofuran congeners and 1,2,3,6,7,8-hexachlorodibenzofuran were associated with a decreased enjoyment of food score, and seven PCDF congeners were associated with a decreased desire to drink score. The adjusted mean enjoyment of food score was significantly lower in children of both sexes exposed to high levels of TEQ-PCDFs. There was, however, a significant interaction between sex and TEQ-PCDF exposure in their effect on desire to drink scores, especially in girls. Conclusions Perinatal exposure to dioxin can influence eating behavior in children and particularly in girls. A longer follow-up study would be required to assess whether emotional development that affects eating styles and behaviors is related to dioxin exposure.http://link.springer.com/article/10.1186/s12887-018-1171-2DioxinBreast milkPerinatal exposureChildrenEating behaviorVietnam |
| spellingShingle | Anh Thi Nguyet Nguyen Muneko Nishijo Tai The Pham Nghi Ngoc Tran Anh Hai Tran Luong Van Hoang Hitomi Boda Yuko Morikawa Yoshikazu Nishino Hisao Nishijo Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children BMC Pediatrics Dioxin Breast milk Perinatal exposure Children Eating behavior Vietnam |
| title | Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children |
| title_full | Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children |
| title_fullStr | Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children |
| title_full_unstemmed | Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children |
| title_short | Sex-specific effects of perinatal dioxin exposure on eating behavior in 3-year-old Vietnamese children |
| title_sort | sex specific effects of perinatal dioxin exposure on eating behavior in 3 year old vietnamese children |
| topic | Dioxin Breast milk Perinatal exposure Children Eating behavior Vietnam |
| url | http://link.springer.com/article/10.1186/s12887-018-1171-2 |
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