Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the conditi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2011-11-01
|
| Series: | Clinical Ophthalmology |
| Online Access: | http://www.dovepress.com/biological-activity-is-the-likely-origin-of-the-intersection-between-t-a8706 |
| _version_ | 1818852855549788160 |
|---|---|
| author | Yamauchi Y Yagi H Usui Y Kimura K Agawa T Tsukahara R Yamakawa N Goto H |
| author_facet | Yamauchi Y Yagi H Usui Y Kimura K Agawa T Tsukahara R Yamakawa N Goto H |
| author_sort | Yamauchi Y |
| collection | DOAJ |
| description | Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the condition of the intersection between the photoreceptor inner and outer segments (IS/OS) and the relationship with retinal photoreceptor abnormalities. Although the origin of the IS/OS in optical coherence tomography (OCT) images is unclear, it may be related to either the cellular activity of the photoreceptors or the structure of the OS disks. To address this question, we compared the IS/OS status in OCT images of rat retinas before and after euthanasia.Methods: OCT images were taken before and after euthanasia in four eyes of two Brown Norway rats. After the OCT images were taken, the rats were used for histopathological studies to confirm that retinal structures were intact.Results: Before euthanasia, the IS/OS and external limiting membrane (ELM) line were clearly identifiable on the OCT images. However, after euthanasia, neither the IS/OS nor the ELM line was evident in three out of four eyes, and a faint IS/OS and an ELM line were identified in one eye. Histopathological analysis did not show any abnormalities in the retina in any of the four eyes.Conclusion: The origin of the IS/OS identified in OCT images is likely related to the biological activities of the photoreceptor cells.Keywords: IS/OS, OCT, histopathology, biological activity |
| first_indexed | 2024-12-19T07:27:33Z |
| format | Article |
| id | doaj.art-1fc7c2933af44246ae9151702e69f506 |
| institution | Directory Open Access Journal |
| issn | 1177-5467 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T07:27:33Z |
| publishDate | 2011-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-1fc7c2933af44246ae9151702e69f5062022-12-21T20:30:47ZengDove Medical PressClinical Ophthalmology1177-54671177-54832011-11-012011default16491653Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomographyYamauchi YYagi HUsui YKimura KAgawa TTsukahara RYamakawa NGoto HYasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the condition of the intersection between the photoreceptor inner and outer segments (IS/OS) and the relationship with retinal photoreceptor abnormalities. Although the origin of the IS/OS in optical coherence tomography (OCT) images is unclear, it may be related to either the cellular activity of the photoreceptors or the structure of the OS disks. To address this question, we compared the IS/OS status in OCT images of rat retinas before and after euthanasia.Methods: OCT images were taken before and after euthanasia in four eyes of two Brown Norway rats. After the OCT images were taken, the rats were used for histopathological studies to confirm that retinal structures were intact.Results: Before euthanasia, the IS/OS and external limiting membrane (ELM) line were clearly identifiable on the OCT images. However, after euthanasia, neither the IS/OS nor the ELM line was evident in three out of four eyes, and a faint IS/OS and an ELM line were identified in one eye. Histopathological analysis did not show any abnormalities in the retina in any of the four eyes.Conclusion: The origin of the IS/OS identified in OCT images is likely related to the biological activities of the photoreceptor cells.Keywords: IS/OS, OCT, histopathology, biological activityhttp://www.dovepress.com/biological-activity-is-the-likely-origin-of-the-intersection-between-t-a8706 |
| spellingShingle | Yamauchi Y Yagi H Usui Y Kimura K Agawa T Tsukahara R Yamakawa N Goto H Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography Clinical Ophthalmology |
| title | Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography |
| title_full | Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography |
| title_fullStr | Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography |
| title_full_unstemmed | Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography |
| title_short | Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography |
| title_sort | biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography |
| url | http://www.dovepress.com/biological-activity-is-the-likely-origin-of-the-intersection-between-t-a8706 |
| work_keys_str_mv | AT yamauchiy biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT yagih biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT usuiy biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT kimurak biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT agawat biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT tsukaharar biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT yamakawan biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography AT gotoh biologicalactivityisthelikelyoriginoftheintersectionbetweenthephotoreceptorinnerandoutersegmentsoftheratretinaasdeterminedbyopticalcoherencetomography |