A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure
Acute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be given to hemodynamics and metabolic parameter...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/23/7451 |
| _version_ | 1797399890447302656 |
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| author | Nazli Begum Ozturk Emre Herdan Fuat H. Saner Ahmet Gurakar |
| author_facet | Nazli Begum Ozturk Emre Herdan Fuat H. Saner Ahmet Gurakar |
| author_sort | Nazli Begum Ozturk |
| collection | DOAJ |
| description | Acute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be given to hemodynamics and metabolic parameters along with the active surveillance of infections. Timely transfer and supportive management are important in an intensive care unit in a liver transplant center. Identifying patients who will and will not improve with medical management and may need emergent liver transplantation is critical. In this review, we provide a comprehensive update on the etiology, diagnosis, and management of ALF. |
| first_indexed | 2024-03-09T01:47:38Z |
| format | Article |
| id | doaj.art-1fc7f8b08bdb4f02a496822a42276340 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T01:47:38Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1fc7f8b08bdb4f02a496822a422763402023-12-08T15:20:01ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011223745110.3390/jcm12237451A Comprehensive Review of the Diagnosis and Management of Acute Liver FailureNazli Begum Ozturk0Emre Herdan1Fuat H. Saner2Ahmet Gurakar3Department of Internal Medicine, Beaumont Hospital, Royal Oak, MI 48073, USADivision of Gastroenterology and Hepatology, Johns Hopkins University Hospital, Baltimore, MD 21287, USADepartment of General, Visceral and Transplantation Surgery, University of Duisburg-Essen, 45147 Essen, GermanyDivision of Gastroenterology and Hepatology, Johns Hopkins University Hospital, Baltimore, MD 21287, USAAcute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be given to hemodynamics and metabolic parameters along with the active surveillance of infections. Timely transfer and supportive management are important in an intensive care unit in a liver transplant center. Identifying patients who will and will not improve with medical management and may need emergent liver transplantation is critical. In this review, we provide a comprehensive update on the etiology, diagnosis, and management of ALF.https://www.mdpi.com/2077-0383/12/23/7451liver diseasehepatic encephalopathyacetaminophenfulminant hepatitisintensive care |
| spellingShingle | Nazli Begum Ozturk Emre Herdan Fuat H. Saner Ahmet Gurakar A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure Journal of Clinical Medicine liver disease hepatic encephalopathy acetaminophen fulminant hepatitis intensive care |
| title | A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure |
| title_full | A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure |
| title_fullStr | A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure |
| title_full_unstemmed | A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure |
| title_short | A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure |
| title_sort | comprehensive review of the diagnosis and management of acute liver failure |
| topic | liver disease hepatic encephalopathy acetaminophen fulminant hepatitis intensive care |
| url | https://www.mdpi.com/2077-0383/12/23/7451 |
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