Dimethyl Fumarate as Potential Treatment for Alzheimer’s Disease: Rationale and Clinical Trial Design

Dimethyl Fumarate as Potential Treatment for Alzheimer’s Disease: Rationale and Clinical Trial Design

Alzheimer’s Disease (AD) is a debilitating disease that leads to severe cognitive impairment and functional decline. The role of tau hyperphosphorylation and amyloid plaque deposition in the pathophysiology of AD has been well described; however, neuroinflammation and oxidative stress related to sus...

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Bibliographic Details
Main Authors: Robert Sharkus, Richa Thakkar, Dennis L. Kolson, Cris S. Constantinescu
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomedicines
Subjects:
Alzheimer’s Disease
microglia
NRF-2
heme oxygenase
dimethyl fumarate
Online Access:https://www.mdpi.com/2227-9059/11/5/1387

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