Ion Channel Genes in Painful Neuropathies
Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets. Disruption of the cellular mechanisms that govern ion channel activity...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2680 |
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| author | Milena Ślęczkowska Kaalindi Misra Silvia Santoro Monique M. Gerrits Janneke G. J. Hoeijmakers |
| author_facet | Milena Ślęczkowska Kaalindi Misra Silvia Santoro Monique M. Gerrits Janneke G. J. Hoeijmakers |
| author_sort | Milena Ślęczkowska |
| collection | DOAJ |
| description | Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets. Disruption of the cellular mechanisms that govern ion channel activity can contribute to pain pathophysiology. The voltage-gated sodium channel (VGSC) is the most researched ion channel in terms of NP; however, VGSC impairment is detected in only <20% of painful neuropathy patients. Here, we discuss the potential role of the other peripheral ion channels involved in sensory signaling (transient receptor potential cation channels), neuronal excitation regulation (potassium channels), involuntary action potential generation (hyperpolarization-activated cyclic nucleotide-gated channels), thermal pain (anoctamins), pH modulation (acid sensing ion channels), and neurotransmitter release (calcium channels) related to pain and their prospective role as therapeutic targets for painful neuropathy. |
| first_indexed | 2024-03-10T21:25:12Z |
| format | Article |
| id | doaj.art-1fc93650b37148679eea92ac8e45e0ee |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:25:12Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1fc93650b37148679eea92ac8e45e0ee2023-11-19T15:45:33ZengMDPI AGBiomedicines2227-90592023-09-011110268010.3390/biomedicines11102680Ion Channel Genes in Painful NeuropathiesMilena Ślęczkowska0Kaalindi Misra1Silvia Santoro2Monique M. Gerrits3Janneke G. J. Hoeijmakers4Department of Toxicogenomics, Maastricht University, 6229 ER Maastricht, The NetherlandsLaboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, INSPE, 20132 Milan, ItalyLaboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, INSPE, 20132 Milan, ItalyDepartment of Clinical Genetics, Maastricht University Medical Centre+, 6229 HX Maastricht, The NetherlandsDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Centre+, 6229 ER Maastricht, The NetherlandsNeuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets. Disruption of the cellular mechanisms that govern ion channel activity can contribute to pain pathophysiology. The voltage-gated sodium channel (VGSC) is the most researched ion channel in terms of NP; however, VGSC impairment is detected in only <20% of painful neuropathy patients. Here, we discuss the potential role of the other peripheral ion channels involved in sensory signaling (transient receptor potential cation channels), neuronal excitation regulation (potassium channels), involuntary action potential generation (hyperpolarization-activated cyclic nucleotide-gated channels), thermal pain (anoctamins), pH modulation (acid sensing ion channels), and neurotransmitter release (calcium channels) related to pain and their prospective role as therapeutic targets for painful neuropathy.https://www.mdpi.com/2227-9059/11/10/2680neuropathic painion channel genesneuropathyvariantspathophysiologychannelopathies |
| spellingShingle | Milena Ślęczkowska Kaalindi Misra Silvia Santoro Monique M. Gerrits Janneke G. J. Hoeijmakers Ion Channel Genes in Painful Neuropathies Biomedicines neuropathic pain ion channel genes neuropathy variants pathophysiology channelopathies |
| title | Ion Channel Genes in Painful Neuropathies |
| title_full | Ion Channel Genes in Painful Neuropathies |
| title_fullStr | Ion Channel Genes in Painful Neuropathies |
| title_full_unstemmed | Ion Channel Genes in Painful Neuropathies |
| title_short | Ion Channel Genes in Painful Neuropathies |
| title_sort | ion channel genes in painful neuropathies |
| topic | neuropathic pain ion channel genes neuropathy variants pathophysiology channelopathies |
| url | https://www.mdpi.com/2227-9059/11/10/2680 |
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