Lis1 regulates dynein by sterically blocking its mechanochemical cycle

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development. The dynein regulator Lis1 is known to keep dynein bound to microtubules; however, how this is accomplished mechanistically re...

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Bibliographic Details
Main Authors: Katerina Toropova, Sirui Zou, Anthony J Roberts, William B Redwine, Brian S Goodman, Samara L Reck-Peterson, Andres E Leschziner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
dynein
electron microscopy
Lis1
microtubules
structure
Online Access:https://elifesciences.org/articles/03372

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