Association between ocular abnormalities and systemic diseases in Down Syndrome patients

Abstract Objectives: Describe ocular findings and its correlation with systemic diseases in Down Syndrome (DS) pediatric patients. Methods: Quantitative and cross-sectional study of prevalence with children aged from 0 to 25 years. Standard ophthalmic examinations performed: visual acuity, slit lam...

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Main Authors: Maria Isabela Zago, Mateus Campestrini Harger, Caroline Possamai, Maria Claudia Schmitt Lobe, Charles Zwicker, Hamilton Rosendo Fogaça, Fernando Marcondes Penha
Format: Article
Language:English
Published: Sociedade Brasileira de Oftalmologia 2020-08-01
Series:Revista Brasileira de Oftalmologia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802020000300174&tlng=en
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author Maria Isabela Zago
Mateus Campestrini Harger
Caroline Possamai
Maria Claudia Schmitt Lobe
Charles Zwicker
Hamilton Rosendo Fogaça
Fernando Marcondes Penha
author_facet Maria Isabela Zago
Mateus Campestrini Harger
Caroline Possamai
Maria Claudia Schmitt Lobe
Charles Zwicker
Hamilton Rosendo Fogaça
Fernando Marcondes Penha
author_sort Maria Isabela Zago
collection DOAJ
description Abstract Objectives: Describe ocular findings and its correlation with systemic diseases in Down Syndrome (DS) pediatric patients. Methods: Quantitative and cross-sectional study of prevalence with children aged from 0 to 25 years. Standard ophthalmic examinations performed: visual acuity, slit lamp biomicroscopy, ocular motility, static refraction and indirect ophthalmoscopy. Ocular findings were associated with comorbidities available in pediatric records of patients in FURB Down Syndrome Outpatient clinic, in which they have regular follow-up. Results: A total of 76 patients were evaluated (33 males and 43 females). Of these, 72 patients (94.73%) had ocular abnormalities. Refractive errors were the most prevalent (94.73%), followed by alterations in indirect ophthalmoscopy (40.8%), biomicroscopy (15.8%), ocular motility (15.8%) and epiphora (9.2%). From the refractive changes 13.15% had myopia; 76.31% had hypermetropia and 47.36% had astigmatism. Sytemic abnormalities were observed in 73 children. The most prevalent was thyroid diseases presented in 65.79%, followed by heart disease 61.84%, gastrointestinal disease (15.79%); abdominal hernias (14.4%); respiratory changes (14.4%); genitourinary alterations (10.53%); musculoskeletal alterations (10.53%) and epilepsy (3.95%). There was statically significant association between the presence of myopia and hypothyroidism (p = 0.01); astigmatism and heart diseases (p = 0.003); and astigmatism and genitourinary alterations (p = 0.001). Conclusion: There was a high prevalence of ophthalmologic abnormalities in this study of children with Down Syndrome. Associations between myopia and hypothyroidism, astigmatism and heart diseases, and astigmatism and genitourinary disorders were found. More studies and increase of the sample are necessary to confirm the associations of ophthalmologic abnormalities with most common systemic diseases in this population.
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spelling doaj.art-1fcb52a8c521443591a4be68c0992cc82022-12-21T19:28:48ZengSociedade Brasileira de OftalmologiaRevista Brasileira de Oftalmologia1982-85512020-08-0179317417910.5935/0034-7280.20200038Association between ocular abnormalities and systemic diseases in Down Syndrome patientsMaria Isabela Zagohttps://orcid.org/0000-0002-7711-0019Mateus Campestrini Hargerhttps://orcid.org/0000-0001-6221-0482Caroline Possamaihttps://orcid.org/0000-0001-5193-1698Maria Claudia Schmitt Lobehttps://orcid.org/0000-0001-5383-4023Charles Zwickerhttps://orcid.org/0000-0002-7404-5370Hamilton Rosendo Fogaçahttps://orcid.org/0000-0001-9985-058XFernando Marcondes Penhahttps://orcid.org/0000-0002-1038-5472Abstract Objectives: Describe ocular findings and its correlation with systemic diseases in Down Syndrome (DS) pediatric patients. Methods: Quantitative and cross-sectional study of prevalence with children aged from 0 to 25 years. Standard ophthalmic examinations performed: visual acuity, slit lamp biomicroscopy, ocular motility, static refraction and indirect ophthalmoscopy. Ocular findings were associated with comorbidities available in pediatric records of patients in FURB Down Syndrome Outpatient clinic, in which they have regular follow-up. Results: A total of 76 patients were evaluated (33 males and 43 females). Of these, 72 patients (94.73%) had ocular abnormalities. Refractive errors were the most prevalent (94.73%), followed by alterations in indirect ophthalmoscopy (40.8%), biomicroscopy (15.8%), ocular motility (15.8%) and epiphora (9.2%). From the refractive changes 13.15% had myopia; 76.31% had hypermetropia and 47.36% had astigmatism. Sytemic abnormalities were observed in 73 children. The most prevalent was thyroid diseases presented in 65.79%, followed by heart disease 61.84%, gastrointestinal disease (15.79%); abdominal hernias (14.4%); respiratory changes (14.4%); genitourinary alterations (10.53%); musculoskeletal alterations (10.53%) and epilepsy (3.95%). There was statically significant association between the presence of myopia and hypothyroidism (p = 0.01); astigmatism and heart diseases (p = 0.003); and astigmatism and genitourinary alterations (p = 0.001). Conclusion: There was a high prevalence of ophthalmologic abnormalities in this study of children with Down Syndrome. Associations between myopia and hypothyroidism, astigmatism and heart diseases, and astigmatism and genitourinary disorders were found. More studies and increase of the sample are necessary to confirm the associations of ophthalmologic abnormalities with most common systemic diseases in this population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802020000300174&tlng=enDown SyndromeRefractive errorsChildComorbidity
spellingShingle Maria Isabela Zago
Mateus Campestrini Harger
Caroline Possamai
Maria Claudia Schmitt Lobe
Charles Zwicker
Hamilton Rosendo Fogaça
Fernando Marcondes Penha
Association between ocular abnormalities and systemic diseases in Down Syndrome patients
Revista Brasileira de Oftalmologia
Down Syndrome
Refractive errors
Child
Comorbidity
title Association between ocular abnormalities and systemic diseases in Down Syndrome patients
title_full Association between ocular abnormalities and systemic diseases in Down Syndrome patients
title_fullStr Association between ocular abnormalities and systemic diseases in Down Syndrome patients
title_full_unstemmed Association between ocular abnormalities and systemic diseases in Down Syndrome patients
title_short Association between ocular abnormalities and systemic diseases in Down Syndrome patients
title_sort association between ocular abnormalities and systemic diseases in down syndrome patients
topic Down Syndrome
Refractive errors
Child
Comorbidity
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802020000300174&tlng=en
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