The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26775-x |
| _version_ | 1818402733800030208 |
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| author | Kay Oliver Schink Kia Wee Tan Hélène Spangenberg Domenica Martorana Marte Sneeggen Virginie Stévenin Jost Enninga Coen Campsteijn Camilla Raiborg Harald Stenmark |
| author_facet | Kay Oliver Schink Kia Wee Tan Hélène Spangenberg Domenica Martorana Marte Sneeggen Virginie Stévenin Jost Enninga Coen Campsteijn Camilla Raiborg Harald Stenmark |
| author_sort | Kay Oliver Schink |
| collection | DOAJ |
| description | Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks. |
| first_indexed | 2024-12-14T08:13:04Z |
| format | Article |
| id | doaj.art-1fcda7e0cf7b4a7696d8bc77022c3d9e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:13:04Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1fcda7e0cf7b4a7696d8bc77022c3d9e2022-12-21T23:10:01ZengNature PortfolioNature Communications2041-17232021-11-0112111710.1038/s41467-021-26775-xThe phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomesKay Oliver Schink0Kia Wee Tan1Hélène Spangenberg2Domenica Martorana3Marte Sneeggen4Virginie Stévenin5Jost Enninga6Coen Campsteijn7Camilla Raiborg8Harald Stenmark9Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloDepartment of Cell and Chemical Biology, Leiden University Medical CenterInstitut Pasteur, Dynamics of Host-Pathogen Interactions UnitDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, MontebelloMacropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.https://doi.org/10.1038/s41467-021-26775-x |
| spellingShingle | Kay Oliver Schink Kia Wee Tan Hélène Spangenberg Domenica Martorana Marte Sneeggen Virginie Stévenin Jost Enninga Coen Campsteijn Camilla Raiborg Harald Stenmark The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes Nature Communications |
| title | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes |
| title_full | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes |
| title_fullStr | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes |
| title_full_unstemmed | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes |
| title_short | The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes |
| title_sort | phosphoinositide coincidence detector phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes |
| url | https://doi.org/10.1038/s41467-021-26775-x |
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