Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate
In this paper the synthesis of methyl-6- methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1-3) were synthesised from substituted benzaldehyde, urea and methyl acetoacetate, substituted pyrimidine (1-3) were treated with hydrazine hydrate in butanol to give acid hydrazide...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
2018-03-01
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| Series: | مجلة التربية والعلم |
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| Online Access: | https://edusj.mosuljournals.com/article_147571_1834d591a8860c66e6af0826111fa979.pdf |
| Summary: | In this paper the synthesis of methyl-6- methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1-3) were synthesised from substituted benzaldehyde, urea and methyl acetoacetate, substituted pyrimidine (1-3) were treated with hydrazine hydrate in butanol to give acid hydrazide (4-6), which were converted to hydrazones (7-12) by their reaction with substituted benzaldehyde. Cyclizatian of hydrazones (7-12) with lead dioxide in glacial acetic acid gave substituted 1,3,4- oxadiazole (13-18). Hydrazide (4-6) were treated with ammonium<br /> thiocyanate in ethanol and hydrochloric acid to give substituted<br /> thiosemicarbazides(19-21). Reaction of thiosemicarbazide (19-21) with<br /> 4% sodium hydroxide or with concentrated sulfuric acid gave substituted<br /> 1,2,4- (4H) - triazole (22-24) and 1,3,4- thiadiazole (25-27)<br /> respectively.<br /> The structure of the synthesized compounds, were confirmed by IR, UV<br /> and physical methods. |
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| ISSN: | 1812-125X 2664-2530 |