Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate
In this paper the synthesis of methyl-6- methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1-3) were synthesised from substituted benzaldehyde, urea and methyl acetoacetate, substituted pyrimidine (1-3) were treated with hydrazine hydrate in butanol to give acid hydrazide...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
2018-03-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_147571_1834d591a8860c66e6af0826111fa979.pdf |
| _version_ | 1818932620254248960 |
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| author | Shaima S. Ismmaeel |
| author_facet | Shaima S. Ismmaeel |
| author_sort | Shaima S. Ismmaeel |
| collection | DOAJ |
| description | In this paper the synthesis of methyl-6- methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1-3) were synthesised from substituted benzaldehyde, urea and methyl acetoacetate, substituted pyrimidine (1-3) were treated with hydrazine hydrate in butanol to give acid hydrazide (4-6), which were converted to hydrazones (7-12) by their reaction with substituted benzaldehyde. Cyclizatian of hydrazones (7-12) with lead dioxide in glacial acetic acid gave substituted 1,3,4- oxadiazole (13-18). Hydrazide (4-6) were treated with ammonium<br /> thiocyanate in ethanol and hydrochloric acid to give substituted<br /> thiosemicarbazides(19-21). Reaction of thiosemicarbazide (19-21) with<br /> 4% sodium hydroxide or with concentrated sulfuric acid gave substituted<br /> 1,2,4- (4H) - triazole (22-24) and 1,3,4- thiadiazole (25-27)<br /> respectively.<br /> The structure of the synthesized compounds, were confirmed by IR, UV<br /> and physical methods. |
| first_indexed | 2024-12-20T04:35:23Z |
| format | Article |
| id | doaj.art-1fce305b80644d86b94c8a0083883f70 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-20T04:35:23Z |
| publishDate | 2018-03-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-1fce305b80644d86b94c8a0083883f702022-12-21T19:53:16ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302018-03-0127211410.33899/edusj.2018.147571147571Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylateShaima S. IsmmaeelIn this paper the synthesis of methyl-6- methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1-3) were synthesised from substituted benzaldehyde, urea and methyl acetoacetate, substituted pyrimidine (1-3) were treated with hydrazine hydrate in butanol to give acid hydrazide (4-6), which were converted to hydrazones (7-12) by their reaction with substituted benzaldehyde. Cyclizatian of hydrazones (7-12) with lead dioxide in glacial acetic acid gave substituted 1,3,4- oxadiazole (13-18). Hydrazide (4-6) were treated with ammonium<br /> thiocyanate in ethanol and hydrochloric acid to give substituted<br /> thiosemicarbazides(19-21). Reaction of thiosemicarbazide (19-21) with<br /> 4% sodium hydroxide or with concentrated sulfuric acid gave substituted<br /> 1,2,4- (4H) - triazole (22-24) and 1,3,4- thiadiazole (25-27)<br /> respectively.<br /> The structure of the synthesized compounds, were confirmed by IR, UV<br /> and physical methods.https://edusj.mosuljournals.com/article_147571_1834d591a8860c66e6af0826111fa979.pdfuvinfraredpyrimidinefive membred ring |
| spellingShingle | Shaima S. Ismmaeel Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate مجلة التربية والعلم uv infrared pyrimidine five membred ring |
| title | Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate |
| title_full | Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate |
| title_fullStr | Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate |
| title_full_unstemmed | Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate |
| title_short | Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate |
| title_sort | synthesis of five membered ring hetero cyclic compounds derived from methyl 6 methyl 2 oxo 4 substituted 1 2 3 4 tetrahydro pyrimidine 5 carboxylate |
| topic | uv infrared pyrimidine five membred ring |
| url | https://edusj.mosuljournals.com/article_147571_1834d591a8860c66e6af0826111fa979.pdf |
| work_keys_str_mv | AT shaimasismmaeel synthesisoffivememberedringheterocycliccompoundsderivedfrommethyl6methyl2oxo4substituted1234tetrahydropyrimidine5carboxylate |